Pathophysiologic role of calcium in the development of vascular smooth muscle tone.
Pathophysiologic role of calcium in the development of vascular smooth muscle tone.
复制标题
钙在血管平滑肌张力发展中的病理生理作用。
DOI：
10.1016/0002-9149(89)90744-3
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Jiang,MJ
中科院分区：
文献类型：
--
作者：
Morgan,KG;Papageorgiou,P;Jiang,MJ
最近的资料表明，细胞内离子钙浓度[Ca ~（2+）]i起着调节作用，不仅在确定血管张力的大小，而且在调节血管组织的生长。利用钙指示剂水母发光蛋白对活的血管平滑肌细胞进行的研究表明，[Ca 2 +]i与血管平滑肌细胞收缩之间的关系是复杂的。可能涉及1种以上的细胞内激酶，导致多种兴奋-收缩偶联途径共存。然而，似乎所有这些途径都可能是钙依赖性的。目前尚不清楚人类原发性高血压的原因是否涉及血管平滑肌细胞中[Ca 2 +]i升高。然而，有证据表明，高血压平滑肌细胞中[Ca 2 +]i降低将导致血管张力和总外周阻力降低，并可能拮抗与高血压继发性效应相关的血管平滑肌细胞的生长反应。
Recent information indicates that the intracellular ionized calcium concentration [Ca2+]i plays a regulatory role not only in determining the magnitude of vascular tone but also in regulating growth of vascular tissue. Studies on living vascular smooth muscle cells using the calcium indicator aequorin have revealed that the relation between [Ca2+]i and contraction of the vascular smooth muscle cell is complex. More than 1 intracellular kinase may be involved, leading to the coexistence of multiple excitation-contraction coupling pathways. However, it appears that all of these pathways may be calcium-dependent. It is not yet known whether the cause of human essential hypertension involves an elevated [Ca2+]i in the vascular smooth muscle cell. However, evidence is presented supporting the concept that a decreased [Ca2+]i in the hypertensive smooth muscle cell will lead to a decrease in vascular tone and total peripheral resistance, and possibly also antagonize the growth response of the vascular smooth muscle cell associated with the secondary effects of hypertension.