IMMUNE-COMPLEXES, COMPLEMENT, AND ANTI-DNA IN EXACERBATIONS OF SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE)
IMMUNE-COMPLEXES, COMPLEMENT, AND ANTI-DNA IN EXACERBATIONS OF SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE)
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DOI：
10.1097/00005792-198105000-00004
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发表时间：
1981-01-01
期刊：
影响因子：
1.6
通讯作者：
SCHUR, PH
中科院分区：
文献类型：
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作者：
LLOYD, W;SCHUR, PH
系统性红斑狼疮（SLE）的特征是多种血清学异常，包括补体成分抑制、多种自身抗体以及循环和组织沉积的免疫复合物（3，20，44）。异常血清学结果在疾病活动期更常见，尤其是活动性肾炎（3，7，11，15，16，22，23，39，40，42，44）。已注意到这些异常检查结果随临床活动改善而正常化。然而，很少有研究探讨在不断发展的临床急性加重期间改变定性和定量血清学参数的问题。本研究的目的是检查补体、抗dsDNA抗体（ADA）和免疫复合物水平中哪些血清学参数与活动性肾和非肾性急性加重的发展以及这些变化的时间过程最相关。
Systemic lupus erythematosus (SLE) is characterized by multiple serological aberrations, including complement component depressions, many autoantibodies, and circulating and tissue deposited immune complexes (3, 20, 44). Abnormal serologic findings occur more frequently during periods of active disease, especially active nephritis (3, 7, 11, 15, 16, 22, 23, 39, 40, 42, 44). These abnormal test results have been noted to normalize in association with improvement of clinical activity. There are, however, few studies that address the question of changing qualitative and quantitative serological parameters during evolving clinical exacerbations. The purpose of this study is to examine which serologic parameters among complement, anti-bodies to dsDNA (ADA) and immune complex levels correlated best with the development of ac-tive renal and non-renal exacerbations and the time course of these changes.