LIPOSOMAL RETENTION OF A MODIFIED ANTI-INFLAMMATORY STEROID
LIPOSOMAL RETENTION OF A MODIFIED ANTI-INFLAMMATORY STEROID
复制标题
DOI：
10.1042/bj1580473
复制
发表时间：
1976-01-01
影响因子：
4.1
通讯作者：
DINGLE, JT
中科院分区：
文献类型：
--
作者：
SHAW, IH;KNIGHT, CG;DINGLE, JT
在合成卵磷脂的研究中，二棕榈酰磷脂酰胆碱是 37°C 下皮质醇酯脂质体保留的首选形式。 C. 棕榈酸皮质醇比辛酸皮质醇保留时间更长，而未酯化的皮质醇很容易从脂质体中逸出。这种脂质体组合物可以允许修饰的抗炎剂的受控释放，特别是当用于关节内施用时。
In studies with synthetic lecithins, dipalmitoylphosphatidylcholine was the preferred form for liposomal retention of cortisol esters at 37.degree. C. Cortisol palmitate was retained longer than cortisol octanoate, whereas unesterified cortisol escaped readily from liposomes. Such a liposome composition may allow the controlled release of modified anti-inflammatory agents, particularly when used for intra-articular administration.