TERFENADINE, A POTENT HISTAMINE H1-RECEPTOR ANTAGONIST IN THE TREATMENT OF GRASS-POLLEN SENSITIVE ASTHMA
TERFENADINE, A POTENT HISTAMINE H1-RECEPTOR ANTAGONIST IN THE TREATMENT OF GRASS-POLLEN SENSITIVE ASTHMA
复制标题
DOI：
10.1111/j.1365-2125.1990.tb03769.x
复制
发表时间：
1990-08-01
影响因子：
3.4
通讯作者：
HOLGATE, ST
中科院分区：
文献类型：
--
作者：
RAFFERTY, P;JACKSON, L;HOLGATE, ST
1我们评估了特异性组胺H1受体拮抗剂特非那定在草花粉季节治疗特应性哮喘的效果。2 18例轻度、草花粉敏感性哮喘患者（10例女性，8例男性，平均值± 0.05）。S.E.平均年龄34.7岁。5.6年），所有这些人都仅用吸入的β 2-肾上腺素受体激动剂控制，他们参加了一项为期9周的双盲交叉研究，使用特非那定180 mg每日三次和安慰剂。在整个研究过程中，患者每天记录两次呼气峰流速（PEFR），咳嗽、喘息、呼吸困难和胸闷症状（评分为0 - 3分），以及支气管扩张剂的使用情况。每周进行乙酰甲胆碱吸入激发试验。采用适合于两组、两阶段交叉试验的方法对数据进行分析。3特非那定能明显减轻咳嗽症状76.9%（P <0.05）和喘息症状46.9%（P <0.02）。呼吸困难和胸闷的症状分别减少了16.8%和30.3%，但这些没有统计学意义。特非那定治疗后晨间和夜间PEFR分别上升5.5%（P <0.001）和6.2%（P <0.003），支气管扩张剂使用率下降40.3%。在整个研究期间，在两个治疗组中均观察到乙酰甲胆碱敏感性进行性增加，但未达到统计学显著性。4.我们得出结论，在草花粉季节，特非那定治疗敏感性哮喘患者可减轻其症状和支气管扩张剂需求，并适度改善其肺功能，而不会影响草花粉季节发生的乙酰甲胆碱敏感性增加。
1 We have assessed the effect of a specific histamine H1-receptor antagonist, terfenadine, in the treatment of atopic asthmatics during the grass pollen season. 2 Eighteen mild, grass pollen sensitive asthmatics (10F, 8M, mean .+-. s.e. mean age 34.7 .+-. 5.6 years), all of whom were controlled on inhaled .beta.2-adrenoceptor agonists alone, took part in a 9 week, double-blind, crossover study using terfenadine 180 mg three times daily and placebo. Throughout the study patients recorded peak expiratory flow rate (PEFR) twice daily, symptoms of cough, wheeze, breathlessness and chest tightness (scored 0-3), and their use of bronchodilators. Methacholine inhalation challenge tests were performed each week. Data were analysed by a method suitable for a two group, two period crossover trial with baseline measurements. 3 Terfenadine significantly reduced symptoms of cough by 76.9% (P < 0.05) and wheeze by 46.9% (P < 0.02). Symptoms of breathlessness and chest tightness were reduced by 16.8 and 30.3% respectively but these were not statistically significant. Morning and evening PEFR rose by 5.5 (P < 0.001) and 6.2% (P < 0.003) respectively on treatment with terfenadine and bronchodilator use fell by 40.3%. A progressive increase in methacholine sensitivity was seen in both treatment groups throughout the study but did not reach statistical significance. 4 We conclude that treatment with terfenadine during the grass pollen season in sensitive asthmatics reduced their symptoms and bronchodilator requirements and produced a modest improvement in their lung function without affecting the development of increased methacholine sensitivity that occurred during the grass pollen season.