The effects of antibiotic use on gastrointestinal function
The effects of antibiotic use on gastrointestinal function
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DOI：
10.1016/s0002-9270(99)00808-4
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发表时间：
2000-01-01
影响因子：
9.8
通讯作者：
Levy, J
中科院分区：
文献类型：
--
作者：
Levy, J
胃肠道（GI）的细菌植物群在维持肠上皮细胞的完整性、调节代谢和免疫过程以及保护免受侵入性病原体的定殖方面起重要作用。抗生素、感染、化疗或辐射对这种精细调节和稳定的肠道植物群的破坏对保护屏障具有深远的影响，并导致病原体的过度生长、毒素的侵入和移位以及危及生命的感染。抗生素的使用促进了耐药微生物的出现，多重抗生素耐药性已成为一个主要的公共卫生问题。在压力（感染、药物）期间，保护性菌种或非致病性酵母菌或乳酸杆菌的灭活已开始显示出在接受多种抗生素的患者管理中的前景，特别是在医院获得性感染中。
The bacterial flora of the gastrointestinal (GI) tract plays an important role in maintaining the integrity of the enterocyte, modulating metabolic and immunologic processes, and protecting against colonization by invasive pathogens. Disruption of this finely tuned and stable gut flora by antibiotics, infection, chemotherapy, or radiation has profound effects on the protective barrier and results in overgrowth by pathogens, invasion and translocation of toxins, and life-threatening infections. Use of antibiotics promotes the emergence of resistant organisms, and multiple-antibiotic resistance has become a major public health issue. Preservation of protective species or recolonization with nonpathogenic yeasts or lactobacilli during periods of stress (infections, drugs) has begun to show promise in the management of patients receiving multiple antibiotics, particularly in hospital-acquired infections.