Growth negatively impacts the life span of mammals
Growth negatively impacts the life span of mammals
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DOI：
10.1046/j.1525-142x.2002.01053.x
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发表时间：
2002-01-01
影响因子：
2.9
通讯作者：
Rollo, CD
中科院分区：
文献类型：
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作者：
Rollo, CD
早在世纪，人们就提出了生长与寿命之间的负相关关系。事实上，通过限制食物来抑制啮齿动物的生长，可以显著延长它们的寿命。然而，随后，增长加剧老龄化率的假设就失宠了。促成这一点的是：（a）个体大小和寿命之间的正相关关系，（B）生长激素的抗衰老作用，（c）事实上，即使是已经完成生长的成熟啮齿动物的寿命也会通过饮食限制而延长。此外，种内分析研究未能提供任何明确的解决方案。本文介绍了实验室大鼠和小鼠的最长寿命与最大成熟体重的首次全球分析，基于20世纪相对全面的研究汇编。峰值体重（这反映了青少年的生长速度）与这两个物种的寿命呈负相关。增长对寿命的影响的近端机制似乎与衰老的自由基和免疫学理论相一致。
A negative intraspecific relationship between growth and longevity was proposed in the early 20th century. Indeed, stunting the growth of rodents by restricting their food dramatically extended life span. Subsequently, however, the hypothesis that growth exacerbates aging rates fell into disfavor. Contributing to this was (a) the establishment of a positive relationship between body size and longevity interspecifically, (b) purported antiaging impacts of growth hormone, and (c) the fact that the longevity of even mature rodents that had completed growth was extended by dietary restriction. Furthermore, intraspecific analytical studies failed to provide any clear resolution. This article presents the first global analyses of maximal longevity versus maximum mature mass for laboratory rats and mice, based on a relatively comprehensive compilation of research across the 20th century. Peak body mass (which reflects juvenile growth rates) was negatively associated with longevity within both species. Proximal mechanisms for impacts of growth on longevity appear congruent with the free radical and immunological theories of aging.