Elevated plasma 6‐keto‐prostaglandin F1α in patients in septic shock
Elevated plasma 6‐keto‐prostaglandin F1α in patients in septic shock
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感染性休克患者血浆 6-酮-前列腺素 F1α 升高
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
W. C. Wise
中科院分区：
文献类型：
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作者：
P. Halushka;H. Reines;S. Barrow;I. Blair;C. Dollery;W. Rambo;J. Cook;W. C. Wise
本文测定了感染性休克患者中心静脉血中前列环素的稳定水解物--前列环素的稳定水解物--6-酮-前列腺素F1受体(6-keto-prostaglandin F1α，α)浓度。在8例死亡患者中，血浆6-酮-前列腺素F1α水平中位数为229pg/ml(范围31至21,998)，而6例存活患者的血浆6-酮-前列腺素F1 mRNA水平中位数为30 pg/ml(范围22至194)。3例未发生败血症或休克的对照组血浆6-酮-前列腺素F1α水平均低于4pg/ml，提示败血症休克与血浆6-酮-前列腺素F_1水平升高有关，提示PGI_2生成增加可能在感染性休克中起一定作用。
Central venous plasma concentrations of 6-keto-prostaglandin F1α (PGF1α), the stable hydrolysis product of prostacyclin (PGI2, a vasodilator and antiaggregatory metabolite of arachidonic acid), were determined in patients with septic shock. In eight nonsurvivors, the median plasma 6-keto-PGF1α level was 229 pg/ml (range 31 to 21,998), compared to 30 pg/ml (range 22 to 194) in six survivors. In three control patients who were not septic or in shock, the levels were less than 4 pg/ml. This study demonstrates that human septic shock is associated with elevated plasma levels of 6-keto-PGF1α, and raises the possibility that increased PGI2 formation may play a role in human septic shock.