Role of JNK in mammary gland development and breast cancer.
Role of JNK in mammary gland development and breast cancer.
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DOI：
10.1158/0008-5472.can-11-1628
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发表时间：
2012-01-15
期刊：
影响因子：
11.2
通讯作者：
Davis RJ
中科院分区：
文献类型：
--
作者：
Cellurale C;Girnius N;Jiang F;Cavanagh-Kyros J;Lu S;Garlick DS;Mercurio AM;Davis RJ
JNK信号转导与上皮器官的发育形态发生有关。在这项研究中，我们采用了一种复合删除的小鼠Jnk 1和Jnk 2基因在乳腺评估的要求，这些普遍表达的基因在乳腺发育和肿瘤发生。JNK 1/2不是乳腺上皮细胞增殖或运动所必需的。然而，JNK 1/2缺陷导致增加的分支形态和缺陷的管腔上皮细胞的清除。在乳腺癌发展的背景下，JNK 1/2缺陷显著增加肿瘤形成。总之，这些发现确定JNK信号传导是正常乳腺发育所需的，并且在乳腺肿瘤发生中具有抑制作用。
JNK signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clearance of lumenal epithelial cells. In the setting of breast cancer development, JNK1/2 deficiency significantly increased tumor formation. Together, these findings established that JNK signaling is required for normal mammary gland development and that it has a suppressive role in mammary tumorigenesis.