Strain variation in the response of body temperature to dietary restriction
Strain variation in the response of body temperature to dietary restriction
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DOI：
10.1016/s0047-6374(03)00003-4
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发表时间：
2003-05-01
影响因子：
5.3
通讯作者：
Johnson, TE
中科院分区：
文献类型：
--
作者：
Rikke, BA;Yerg, JE;Johnson, TE
饮食限制（DR，也称为热量限制、能量限制和食物限制）可以延缓哺乳动物的衰老并延长其寿命。 DR 还会降低平均体温 (T-b)，因此平均 T-b 可能可作为 DR 引起的寿命延长的协变量。事实上，较低的 T-b 本身可能是 DR 期间发生的一些有益的延长寿命效应的基础。为了评估 DR 期间较低的 Tb 与寿命延长之间的关系，我们询问随意喂食 60% (AL) 的小鼠的 T-b 反应中是否存在显着的应变变化。对来自 28 个品系的单独饲养的雌性小鼠进行了直接比较，这些小鼠代表了经典近交品系的谱系多样性样本。响应 DR 的平均 T(b)s 表现出高度显着的应变变化，范围从低于正常值 1.5 摄氏度到低于正常值 5 摄氏度。这种差异不能用体温调节丧失、AL 肥胖、对非适应性低温的敏感性、运动活动、热唤醒、绝对食物摄入量或营养提取效率的差异来解释。在没有休眠的情况下，应变平均 T-b 的变化也存在。这种应变变化可用于严格测试较低的 T-b 是否是 DR 期间寿命延长的协变量。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
Dietary restriction (DR, also referred to as calorie restriction, energy restriction, and food restriction) retards senescence and increases longevity in mammals. DR also lowers mean body temperature (T-b), and thus mean T-b might be useful as a covariate of DR-induced life extension. Indeed, lower T-b could itself underlie some of the beneficial life-extension effects that occur during DR. Towards assessing the relationship between lower Tb during DR and life extension, we asked whether significant strain variation exists in the T-b response of mice being fed 60% ad libitum (AL). Individually-housed, female mice from 28 strains, representing a genealogically diverse sample of the classical inbred strains, were directly compared. The mean T(b)s in response to DR exhibited highly significant strain variation, ranging from 1.5 degreesC below normal to a phenomenal 5 degreesC below normal. This variation was not explained by differences in loss of thermoregulation, AL adiposity, sensitivity to a nonadaptive hypothermia, motor activity, thermal arousal, absolute food intake, or efficacy of nutrient extraction. The variation in strain mean T-b was also present in the absence of torpor. This strain variation could be used to critically test whether lower T-b is a covariate of life extension during DR. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.