A longitudinal analysis of salivary flow in control subjects and older adults with type 2 diabetes
A longitudinal analysis of salivary flow in control subjects and older adults with type 2 diabetes
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DOI：
10.1067/moe.2001.112054
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发表时间：
2001-02-01
期刊：
影响因子：
--
通讯作者：
Ship, JA
中科院分区：
文献类型：
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作者：
Chávez, EM;Borrell, LN;Ship, JA
目标。许多糖尿病患者抱怨口干症，这种疾病会影响口腔健康、营养状况和饮食选择。本研究的目的是：(1)调查2型糖尿病患者唾液流量的影响以及一组老年人血糖控制的变化，(2)比较唾液流量与口干的主观主诉。研究设计。共有39名老年人参加了为期1年的随访研究，其中24名患有2型糖尿病，15名非糖尿病（对照组），年龄在54-90岁之间。通过糖化血红蛋白（HbA(1c)）水平和2小时葡萄糖耐量试验来确定糖尿病状态。血糖控制不良定义为HbA(1c) bbb9%。在基线和1年后，由一名检查员测量所有受试者的未刺激的整个腮腺、未刺激的腮腺和刺激的腮腺唾液流率。每位受试者在每次访问时完成一份标准化的口干问卷。年龄、性别和糖尿病病程对唾液流速没有不利影响。糖尿病控制不佳的受试者在两次就诊时受刺激的腮腺唾液流速明显降低。在糖尿病状态或血糖控制的基础上，血流速率随时间没有显著变化。糖尿病患者在1年内报告了更多的口渴主诉，而不是口干。这些结果表明，与控制较好的糖尿病患者和非糖尿病患者相比，糖尿病控制较差的老年人可能有唾液流动受损，但他们可能没有伴有口干症状。在1年的时间里，唾液流率和血糖控制没有明显的变化。
Objective. Many diabetics complain of xerostomia, a condition that can affect oral health, nutritional status, and diet selection. This study's purposes were (1) to investigate the effect on salivary flow of type 2 diabetes and change in glycemic control in a group of older adults over time and (2) to compare flow rates with subjective complaints of xerostomia.Study design. A total of 39 older adults, 24 with type 2 diabetes and 15 who were nondiabetic (controls), aged 54-90 years, participated in a 1-year follow-up study. Diabetic status was determined by means of glycosylated hemoglobin (HbA(1c)) levels and 2-hour glucose tolerance tests. Poor glycemic control was defined as HbA(1c) > 9%. Unstimulated whole, unstimulated parotid, and stimulated parotid saliva flow rates were measured for all subjects by a single examiner at baseline and 1 year later. Each subject completed a standardized xerostomia questionnaire at every visit.Results. Age, sex, and duration of diabetes did not adversely affect salivary flow rates. Subjects with poorly controlled diabetes had significantly lower stimulated parotid saliva flow rates at both visits. There were no significant changes in flow rates over time on the basis of diabetic status or glycemic control. Subjects with diabetes reported significantly more complaints of thirst but not of xerostomia at 1 year.Conclusions. These results suggest that older adults with poorly controlled diabetes may have impaired salivary flow in comparison with subjects with better controlled diabetes and nondiabetic subjects, yet they may not have concomitant xerostomic complaints. There were no significant changes in salivary flow rates or glycemic control over the 1-year period.