Ongoing oxidative stress in individuals with post-acute sequelae of COVID-19.
Ongoing oxidative stress in individuals with post-acute sequelae of COVID-19.
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DOI：
10.1515/nipt-2022-0006
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发表时间：
2023-06
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由SARS-CoV-2感染引起的2019冠状病毒病（COVID-19）与氧化应激引起的血浆谷胱甘肽（GSH）水平降低有关。然而，血浆水平可能不能反映脑GSH水平。患有COVID-19急性后遗症（PASC）的个体认知疲劳的患病率较高，这可能与大脑γ-氨基丁酸（GABA）水平的改变有关。因此，我们的研究旨在测量PASC脑GSH和GABA水平。本研究招募了29名PASC参与者和24名未感染的对照。每一个都进行了详细的神经精神评估和编辑质子MRS（阿达玛编码和重建的大编辑光谱，爱马仕）方法来测量主要是灰质（GM）和主要是白色物质（WM）的大脑额叶体素的GABA和GSH浓度。PASC参与者自COVID-19诊断以来为219 ± 137天。9名PASC患者住院治疗。与对照组相比，PASC患者的两个脑区GABA水平相似，但额叶GM区GSH较低，且与年龄相关的GSH下降幅度更大。PASC参与者的额叶GM GSH水平低于正常水平，表明他们的大脑中存在持续的氧化应激，老年人可能更容易受到氧化应激的影响。
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is associated with lower plasma glutathione (GSH) levels due to oxidative stress. However, plasma levels may not reflect brain GSH levels. Individuals with post-acute sequelae of COVID-19 (PASC) have a higher prevalence of cognitive fatigue, which might be related to altered brain γ-aminobutyric-acid (GABA) levels. Hence, our study aims to measure the brain GSH and GABA levels in PASC. 29 PASC participants and 24 uninfected controls were recruited for this study. Each was evaluated with detailed neuropsychiatric assessments and an edited proton MRS (Hadamard Encoding and Reconstruction of Mega-Edited Spectroscopy, HERMES) method to measure GABA and GSH concentrations in predominantly grey matter (GM) and predominantly white matter (WM) brain frontal voxels. PASC participants were 219 ± 137 days since their COVID-19 diagnosis. Nine individuals with PASC were hospitalized. Compared to controls, individuals with PASC had similar levels of GABA in both brain regions, but lower GSH and greater age-related GSH decline in the frontal GM region. The lower-than-normal frontal GM GSH level in participants with PASC suggest that they have ongoing oxidative stress in the brain, and that older individuals may be even more vulnerable to oxidative stress.