Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake
Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake
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DOI：
10.1037/0735-7044.110.3.451
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发表时间：
1996-06-01
影响因子：
1.9
通讯作者：
Winocur, G
中科院分区：
文献类型：
--
作者：
Greenwood, CE;Winocur, G
给 1 个月大的大鼠喂 4 种高脂肪饮食中的一种（20% 脂肪）或饲料（4.5% 脂肪），持续 3 个月。膳食饱和脂肪酸（SFA）、单不饱和脂肪酸（MUFA）或多不饱和脂肪酸（PUFA）各不相同，因此可以测试它们对认知能力的独立影响。对大鼠进行可变间隔延迟交替任务测试。与喂食食物的老鼠相比，在喂食实验饮食的老鼠中观察到随着时间的推移，学习基本交替规则和记住试验特定信息的能力都会受到损害。损伤程度与饲喂的 SFA 水平高度相关，与 MUFA 或 PUFA 无关。膳食脂肪改变了大脑磷脂酰胆碱脂肪酸的分布，但膜的变化与认知障碍无关。结果表明，认知障碍与 SFA 摄入量直接相关，但表明该机制独立于大量脑膜成分的变化。
One-month-old rats were fed 1 of 4 high-fat diets (20% fat) or chow (4.5% fat) for 3 months. Dietary saturated (SFA), monounsaturated (MUFA), or polyunsaturated (PUFA) fatty acids varied such that their independent effects on cognitive performance could be tested. Rats were tested on a variable-interval delayed-alternation task. Impairment in both the ability to learn the basic alternation rule and remembering trial-specific information over time was observed in rats fed the experimental diets relative to those fed chow. The degree of impairment was highly associated with the level of SFAs fed and independent of the MUFAs or PUFAs. Dietary fat altered brain phosphatidylcholine fatty-acid profile, but the membrane changes did not correlate with cognitive impairment. The results demonstrate that cognitive impairment is directly associated with SFA intake but suggest that the mechanism is independent of bulk brain membrane compositional changes.