Inhibitory Effect of L-Dihydroxyphenylalanine on the Adrenal Venous 17-Hydroxycorticosteroid Response to Surgical Stress in Dogs
Inhibitory Effect of L-Dihydroxyphenylalanine on the Adrenal Venous 17-Hydroxycorticosteroid Response to Surgical Stress in Dogs
复制标题
L-二羟基苯丙氨酸对犬手术应激下肾上腺静脉 17-羟基皮质类固醇反应的抑制作用
DOI：
10.1210/endo-88-6-1404
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发表时间：
1971
期刊：
影响因子：
4.8
通讯作者：
W. Ganong
中科院分区：
文献类型：
--
作者：
G. R. Loon;L. Hilger;A. B. King;A. Boryczka;W. Ganong
在戊巴比妥钠麻醉犬模型上，观察了静脉注射L-二羟基苯丙氨酸(L-多巴)对剖腹和肠道操作后肾上腺静脉血17-羟基皮质类固醇(17uchS)排出量的影响。L多巴50 mg/kg，而不是10 NAG/kg，可显著降低17uchS对手术应激的反应。静脉注射的儿茶酚胺、去甲肾上腺素和多巴胺对17uchS的产生没有这种抑制作用。L多巴抑制应激反应的作用不依赖于其引起的血压升高，因为预先用α-肾上腺素能阻断剂苯氧苯甲胺处理狗，可阻止L-多巴的升压反应，而不改变对17uchS输出的影响。抑制17uchS应激反应的最小有效剂量可被单胺氧化酶抑制剂pargyline降低，被儿茶酚胺合成抑制剂α-甲基酪氨酸增加。这些数据支持一个中心的假说。
The effect of intravenous L-dihydroxyphenylalanine (L-dopa) on the adrenal venous 17-hydroxycorticosteroid (17OHCS) output in response to laparotomy and intestinal manipulation was studied in pentobarbital-anesthetized dogs. L-Dopa, 50 mg/kg but not 10 nag/kg, markedly decreased the 17OHCS response to surgical stress. The catecholamines, norepinephrine and dopamine, administered intravenously, did not have this inhibitory effect on 17OHCS output. The effect of L-dopa in inhibiting the 17OHCS response to stress was not dependent on the increase in blood pressure that it produced, since prior treatment of dogs with the α-adrenergic blocking agent, phenoxybenzamine, prevented the pressor response to L-dopa without altering the effect on 17OHCS output. The minimum effective dose of L-dopa that inhibited the 17OHCS response to stress was decreased by the monoamine oxidase inhibitor, pargyline, and increased by the catecholamine synthesis inhibitor, α-methyl-ptyrosine. These data support the hypothesis of a cen...