Partial lipectomy, but not PVN lesions, increases food hoarding by Siberian hamsters.
Partial lipectomy, but not PVN lesions, increases food hoarding by Siberian hamsters.
复制标题
部分脂肪切除术（而非 PVN 损伤）会增加西伯利亚仓鼠的食物囤积。
DOI：
10.1152/ajpregu.1997.272.3.r783
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Bartness,TJ
中科院分区：
文献类型：
--
作者：
Wood,AD;Bartness,TJ
我们分别通过部分脂肪切除（LIPX）或下丘脑室旁核（PVNx）造成肥胖诱导病变来减少或增加体脂，以检验西伯利亚仓鼠体脂与食物囤积之间的反比关系。我们问了三个问题。1) LIPX减脂后是否会增加食物囤积？2) PVNx后食物囤积减少了吗？PVNx是否影响对LIPX的囤积反应？在模拟洞穴系统中饲养的仓鼠在LIPX后增加了食物囤积，随后又减少到LIPX前的水平，因为身体脂肪通过未操作脂肪垫质量的增加得到了部分补偿。LIPX增加了PVNx仓鼠的体重和食物摄入量，但没有减少食物囤积，LIPX也没有增加PVNx仓鼠的食物囤积。LIPX + PVNx仓鼠的部分体脂补偿表明，受损的PVN并未导致感知能量不足的普遍失败，但确实影响了整合内外能量储存的能力。
We tested the inverse relationship between body fat and food hoarding in Siberian hamsters by decreasing or increasing body fat through partial surgical lipectomy (LIPX) or by making obesity-inducing lesions of the paraventricular nucleus of the hypothalamus (PVNx), respectively. We asked three questions. 1) Is food hoarding increased after body fat loss due to LIPX? 2) Is food hoarding decreased after PVNx? 3) Does PVNx affect the hoarding response to LIPX? Hamsters housed in a simulated burrow system increased food hoarding after LIPX followed by a decrease to pre-LIPX levels as body fat was partially compensated through an increase in the mass of their unoperated fat pads. PVNx hamsters had increased body mass and food intake but did not have decreased food hoarding, nor was food hoarding increased by LIPX in PVNx hamsters. The partial body fat compensation by LIPX + PVNx hamsters suggests that the damaged PVN did not cause a general failure to sense energy deficits but did affect the ability to integrate internal and external energy stores.