Efficient route to RIKEN click probes for glycoconjugation
Efficient route to RIKEN click probes for glycoconjugation
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DOI：
10.1080/07328303.2019.1578886
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发表时间：
2019-03-21
影响因子：
1
通讯作者：
Tanaka, Katsunori
中科院分区：
文献类型：
--
作者：
Nakamura, Kayo;Tsubokura, Kazuki;Tanaka, Katsunori
建立了一种简便的RIKEN点击探针，用于将糖共轭到赖氨酸的氨基上。用新方法制备的人血清白蛋白N-糖簇显示出与先前合成的相同的细胞相互作用轮廓。因此，新路线极大地扩展了对糖结合和药物输送系统的适用性。
A convenient route to RIKEN click probes for glycoconjugation to the amino groups of lysines was established. N-Glycoclusters prepared with human serum albumin by the new method showed the same cell interaction profiles as those synthesized previously. The new route has thus significantly expanding the applicability to glycoconjugation and drug delivery systems.[GRAPHICS].