Role of renal cortical sulfhydryl groups in development of mercury-induced renal toxicity.
Role of renal cortical sulfhydryl groups in development of mercury-induced renal toxicity.
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肾皮质巯基在汞引起的肾毒性发展中的作用。
DOI：
10.1080/15287398209530147
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Johnson,DR
中科院分区：
文献类型：
--
作者：
Johnson,DR
在接受HgCl 2（15 mg/kg体重，肌肉注射）的大鼠中评价了降低肾皮质巯基浓度对急性肾衰竭（ARF）发展的影响。在注射HgCl 2后90 min内，尿流率和钠排泄分数（FENa）显著高于对照水平，并在整个3 h实验期间保持升高。注射马来酸二乙酯（3 mmol/kg，ip）前30 min和注射后90 min（DEM/HgCl 2），尿流率和FENa均未显著高于对照水平。单用DEM不改变肾功能。尽管低于对照水平，但HgCl 2和DEM/HgCl 2处理动物的蛋白结合巯基（PBSH）浓度相当。与此相反，非蛋白巯基（NPSH）的浓度在DEM/HgCl 2的动物比单独用HgCl 2处理的动物低62%。类似地，DEM/HgCl 2处理的动物中的汞积累比单独用HgCl 2处理的动物低54%。这些结果表明，NPSH在汞的吸收和汞毒性的发展中起着重要的作用。
The effect of lowering renal cortical sulfhydryl concentration on development of acute renal failure (ARF) was evaluated in rats receiving HgCl2(15 mg/kg body weight, im). Within 90 min after HgCl2injection urine flow rate and fractional excretion of sodium (FENa) were significantly elevated above control levels, and they remained elevated throughout the 3‐h experimental period. Urine flow rate and FENawere not significantly elevated above control levels in animals injected with diethyl maléate (3 mmol/kg, ip) 30 min before and 90 min after HgCl2(DEM/HgCl2). Administration of DEM alone did not alter renal function. Although lower than control levels, concentrations of protein‐bound sulfhydryl groups (PBSH) were comparable in HgCl2‐ and DEM/HgCl2‐treated animals. In contrast, concentrations of nonprotein sulfhydryl groups (NPSH) were 62% lower in DEM/HgCl2animals than in those treated with HgCl2alone. Similarly, Hg accumulation was 54% lower in DEM/HgCl2‐treated animals than in animals treated with HgCl2alone. These results suggest that NPSH play an Important role in Hg uptake and subsequent development of Hg toxicity.
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二硫苏糖醇对氯化汞和硝酸铀酰诱导的大鼠急性肾衰竭的影响。
影响因子：
19.6
作者：
J. Kleinman;J. S. McNeil;J. Schwartz;R. Hamburger;W. Flamenbaum
通讯作者：
W. Flamenbaum
急性肾衰竭病理生理学的最新概念。
影响因子：
--
作者：
J. H. Stein;M. Lifschitz;L. Barnes
通讯作者：
L. Barnes
汞引起的急性肾衰竭大鼠无尿症发展的肾微穿刺研究。
影响因子：
15.9
作者：
W. Flanigan;D. Oken
通讯作者：
D. Oken
DOI：
10.1111/j.1476-5381.1967.tb00420.x
发表时间：
1967
期刊：
British journal of pharmacology and chemotherapy
影响因子：
--
作者：
T. Clarkson;L. Magos
通讯作者：
L. Magos
肾素免疫对氯化汞和甘油诱导的肾衰竭的影响。
影响因子：
19.6
作者：
W. Flamenbaum;T. Kotchen;D. Oken
通讯作者：
D. Oken