A MAJOR SUSCEPTIBILITY LOCUS TO MURINE LUNG CARCINOGENESIS MAPS ON CHROMOSOME-6
A MAJOR SUSCEPTIBILITY LOCUS TO MURINE LUNG CARCINOGENESIS MAPS ON CHROMOSOME-6
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DOI：
10.1038/ng0293-132
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发表时间：
1993-02-01
期刊：
影响因子：
30.8
通讯作者：
DRAGANI, TA
中科院分区：
文献类型：
--
作者：
GARIBOLDI, M;MANENTI, G;DRAGANI, TA
肺肿瘤是人类死亡的主要原因，虽然吸烟是主要的致病因素，但遗传也起了一定作用。然而，可能的易感遗传因素的识别是困难的，因为他们的低风险。我们利用遗传上对肺肿瘤易感或耐药的小鼠品系，绘制了与肺癌易感性相关的小鼠基因图谱。用83个遗传标记对经顺铂处理的A/J x C3 H/He小鼠的F2群体进行评分。染色体6远端区域，跨越35厘米摩根，包含一个主要的肺肿瘤易感性位点。没有其他染色体区域与肺肿瘤的发生显着相关。
Lung tumours represent a major cause of death in humans, and although smoking represents the main pathogenetic factor, inheritance also plays a part. However, the identification of possible predisposing genetic factors is difficult, because of their low penetrance. We took advantage of murine strains that are genetically susceptible or resistant to lung tumour development, to map murine genes associated with susceptibility to lung carcinogenesis. An F2 population of urethan-treated A/J x C3H/He mice was scored with 83 genetic markers. A chromosome 6 distal region, spanning 35 centiMorgans, contained a major lung tumour susceptibility locus. No other chromosomal region was significantly associated with lung tumour development.