Determination of leachable components from four commercial dental composites by gas and liquid chromatography mass spectrometry
Determination of leachable components from four commercial dental composites by gas and liquid chromatography mass spectrometry
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DOI：
10.1016/s0300-5712(96)00086-3
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发表时间：
1998-03-01
影响因子：
4.4
通讯作者：
Geurtsen, W
中科院分区：
文献类型：
--
作者：
Spahl, W;Budzikiewicz, H;Geurtsen, W
目的：本研究的目的是确定聚合后从各种商业牙科复合树脂洗脱的可沥滤残留（共聚）单体和添加剂的质量和数量。从四种通用混合型复合树脂上聚合的样品分别用甲醇洗脱3天。水然后使用粒子束接口通过气相色谱/质谱或液相色谱/质谱分析所有提取物。在所有聚合的复合树脂样品中，鉴别出（共）单体和各种添加剂以及来自制造过程的污染物。在未聚合树脂中检测到的几乎所有化合物也可在甲醇浸提液中鉴别，但在水浸提液中仅发现少数化合物。从这些中提取的共聚单体TEGDMA的量高于在原代人口腔成纤维细胞培养中报告的细胞毒性。根据我们的结果，我们得出结论，应通过降低凝固材料内可沥滤物质的流动性或通过应用较少的水溶性组分，最大限度地减少复合树脂组分的可浸提量。此外，制造商应声明牙科复合材料的所有成分，以确定产品中可能对患者和牙科人员造成不良副作用的物质。(C)1998爱思唯尔科技有限公司版权所有。
Objectives: The purpose of our study was to determine the quality and quantity of leachable residual (co)monomers and additives eluted from various commercial dental composite resins after polymerization.Methods. Polymerized specimens from four universal hybrid-type composite resins were eluted for 3 days with methanol resp. water. Then all extracts were analysed by gas chromatography/mass spectrometry or liquid chromatography/mass spectrometry using a particle beam interface.Results. In all polymerized composite resin specimens, (co)monomers and various additives as well as contaminants from manufacturing processes were identified. Almost every compound detected in the unpolymerized resins could also be identified in the methanol extracts, but only a few of them were found in the water extracts. From these the co-monomer TEGDMA was extracted in quantities higher than those reported to be cytotoxic in primary human oral fibroblast cultures.Conclusions. From our results we conclude that the extractable quantities of composite resin components should be minimized, either by reducing the mobility of leachable substances within the set material or by applying less water-soluble components. Furthermore, all ingredients of a dental composite should be declared by the manufacturers, in order to identify those substances in a product which may cause adverse side effects in patients and dental personnel. (C) 1998 Elsevier Science Ltd. All rights reserved.