CYCLIC GMP AND CELL MOVEMENT
CYCLIC GMP AND CELL MOVEMENT
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DOI：
10.1038/245458a0
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发表时间：
1973-01-01
期刊：
影响因子：
64.8
通讯作者：
GOLDBERG, ND
中科院分区：
文献类型：
--
作者：
ESTENSEN, RD;HILL, HR;GOLDBERG, ND
哺乳动物细胞的运动可被模拟或引起细胞内环3′，5 ′-腺苷一磷酸（环AMP）1，2水平升高的试剂抑制。Goldberg及其同事3，4提出，在许多细胞类型中，环3′，5 ′-鸟苷一磷酸（环GMP）促进的细胞事件与环AMP介导的事件具有拮抗作用。检验这一假设的一种方法是检查刺激细胞环GMP浓度增加的药物对白细胞趋化性的影响。佛波醇肉豆蔻酸酯（PMA）5和乙酰胆碱（Ach）3似乎对一种以上的细胞类型产生这种作用，因此这些化合物被用来研究环GMP可能在调节细胞运动中起作用的可能性。
THE movement of mammalian cells can be inhibited by agents which mimic or produce increases in the intracellular levels of cyclic 3′,5′-adenosine monophosphate (cyclic AMP)1,2. Goldberg and coworkers3,4have proposed that in a number of cell types cyclic 3′,5′-guanosine monophosphate (cyclic GMP) promotes cellular events that are antagonistic to those believed to be mediated by cyclic AMP. One method of testing this hypothesis would be to examine the effects on leukocyte chemotaxis of agents that should stimulate an increase in cellular cyclic GMP concentration. Both phorbol myristate acetate (PMA)5and acetylcholine (Ach)3seem to produce such an effect on more than one cell type and these compounds were therefore used to investigate the possibility that cyclic GMP may play a role in modulating cell movement.