Cohort Profile: The Themba Lethu Clinical Cohort, Johannesburg, South Africa
Cohort Profile: The Themba Lethu Clinical Cohort, Johannesburg, South Africa
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DOI：
10.1093/ije/dys029
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发表时间：
2013-04-01
影响因子：
7.7
通讯作者：
Sanne, Ian M.
中科院分区：
文献类型：
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作者：
Fox, Matthew P.;Maskew, Mhairi;Sanne, Ian M.
Themba Lethu临床队列成立于2004年，允许从一个艾滋病毒治疗地点进行大型患者水平的分析，以评估国家治疗指南，回答国家和国际政策相关性问题，并将经济和流行病学重点结合在艾滋病毒研究上。Themba Lethu临床队列分析目前的目标是：㈠提供关于艾滋病毒治疗结果的队列一级信息; ㈡评价艾滋病毒护理和治疗中与政策相关的方面; ㈢评价艾滋病毒护理和治疗的不同方法的成本和成本效益; ㈣为研究改善艾滋病毒护理和治疗提供一个平台。自2004年以来，Themba Lethu诊所已将约30 000名艾滋病毒阳性患者纳入其艾滋病毒护理和治疗方案，其中21 000多人自入组以来接受了抗逆转录病毒治疗。接受治疗的患者通常至少每3个月观察一次，每6个月至1年进行一次实验室监测。收集的数据包括人口统计学、临床访视数据、实验室数据、用药史和临床诊断。合作分析请求可提交至我们的数据中心。
The Themba Lethu Clinical Cohort was established in 2004 to allow large patient-level analyses from a single HIV treatment site to evaluate National Treatment Guidelines, answer questions of national and international policy relevance and to combine an economic and epidemiologic focus on HIV research. The current objectives of the Themba Lethu Clinical Cohort analyses are to: (i) provide cohort-level information on the outcomes of HIV treatment; (ii) evaluate aspects of HIV care and treatment that have policy relevance; (iii) evaluate the cost and cost-effectiveness of different approaches to HIV care and treatment; and (iv) provide a platform for studies on improving HIV care and treatment. Since 2004, Themba Lethu Clinic has enrolled approximately 30 000 HIV-positive patients into its HIV care and treatment programme, over 21 000 of whom have received anti-retroviral therapy since being enrolled. Patients on treatment are typically seen at least every 3 months with laboratory monitoring every 6 months to 1 year. The data collected include demographics, clinical visit data, laboratory data, medication history and clinical diagnoses. Requests for collaborations on analyses can be submitted to our data centre.