Kidney Function and Prevalent and Incident Frailty
Kidney Function and Prevalent and Incident Frailty
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DOI：
10.2215/cjn.02870313
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发表时间：
2013-12-06
影响因子：
9.8
通讯作者：
Shlipak, Michael G.
中科院分区：
文献类型：
--
作者：
Dalrymple, Lorien S.;Katz, Ronit;Shlipak, Michael G.
背景和目的肾脏疾病与生理改变有关，这些改变可能导致虚弱。本研究旨在调查是否较低水平的肾功能与心血管健康研究（CHS）participators.Design，设置，参与者，和measurementsCHS招募社区居住的成年人年龄65岁之间的普遍或偶发的弱点1989-1990年和1992-1993年。为了检查普遍的脆弱性，纳入了4150名没有中风、帕金森病、阿尔茨海默病或抑郁症的处方药或严重认知障碍的参与者。为了检查事件虚弱，纳入了3459名参与者的子集，这些参与者在随访期间没有基线虚弱或排除标准的制定。主要预测因子是使用血清胱抑素C（eGFR（cys））计算的估计GFR（eGFR）。次要分析使用血清肌酐（eGFR（SCr））检查eGFR。结局为4年随访时的普遍虚弱和偶发虚弱。虚弱的基础上确定的体重减轻，疲惫，虚弱，缓慢，低体力activity.ResultsThe平均年龄为75岁，中位eGFR（cys）为73毫升/分钟每1.73米（2）。在eGFR（cys）
Background and objectivesKidney disease is associated with physiologic changes that may predispose to frailty. This study sought to investigate whether lower levels of kidney function were associated with prevalent or incident frailty in Cardiovascular Health Study (CHS) participants.Design, setting, participants, & measurementsCHS enrolled community-dwelling adults age 65 years between 1989-1990 and 1992-1993. To examine prevalent frailty, included were 4150 participants without stroke, Parkinson disease, prescribed medications for Alzheimer disease or depression, or severely impaired cognition. To examine incident frailty, included were a subset of 3459 participants without baseline frailty or development of exclusion criteria during follow-up. The primary predictor was estimated GFR (eGFR) calculated using serum cystatin C (eGFR(cys)). Secondary analyses examined eGFR using serum creatinine (eGFR(SCr)). Outcomes were prevalent frailty and incident frailty at 4 years of follow-up. Frailty was ascertained on the basis of weight loss, exhaustion, weakness, slowness, and low physical activity.ResultsThe mean age was 75 years and the median eGFR(cys) was 73 ml/min per 1.73 m(2). Among participants with an eGFR(cys)