ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005
ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005
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DOI：
10.1007/s00251-005-0071-4
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发表时间：
2006-01-01
期刊：
影响因子：
3.2
通讯作者：
Marsh, SGE
中科院分区：
文献类型：
--
作者：
Ellis, SA;Bontrop, RE;Marsh, SGE
人类和小鼠以外物种的主要组织相容性复合体（MHC）基因和等位基因的命名历史上一直由产生序列的团体非正式地监督，或由国际动物遗传学学会（ISAG）成立的正式命名委员会监督。在德国哥廷根举行的ISAG会议（2002年）上提出了建立比较MHC命名委员会的建议，该委员会于2003年1月在英国康普顿动物卫生研究所举行了第一次会议。为了宣传其活动并扩大其范围，该委员会在魁北克举行的国际兽医免疫学研讨会（IVIS）上组织了一次研讨会（2004年），并决定与国际免疫学会联合会兽医免疫学委员会（维克）建立联系（IUIS）。该委员会的目标是为任何物种的MHC命名建立一个共同的框架和指导方针;以数据库的形式展示这一点，以确保未来研究人员可以轻松访问任何物种的验证MHC序列的来源;促进现有团体和命名委员会之间在这一领域的讨论。委员会于2005年9月在联合王国格拉斯哥举行了另一次会议。大多数现有的委员会成员以及一些额外的受邀与会者出席了会议（表1）。这次会议的目的是促进将新物种纳入数据库，讨论数据库的扩展、改进和供资问题，并解决上一次研讨会上提出的一些命名问题。
Nomenclature for Major Histocompatibility Complex (MHC) genes and alleles in species other than humans and mice has historically been overseen either informally by groups generating sequences, or by formal nomenclature committees set up by the International Society for Animal Genetics (ISAG). The suggestion for a Comparative MHC Nomenclature Committee was made at the ISAG meeting held in Gottingen, Germany (2002), and the committee met for the first time at the Institute for Animal Health, Compton, UK in January 2003. To publicize its activity and extend its scope, the committee organized a workshop at the International Veterinary Immunology Symposium (IVIS) in Quebec (2004) where it was decided to affiliate with the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS). The goals of the committee are to establish a common framework and guidelines for MHC nomenclature in any species; to demonstrate this in the form of a database that will ensure that in the future, researchers can easily access a source of validated MHC sequences for any species; to facilitate discussion on this area between existing groups and nomenclature committees. A further meeting of the committee was held in September 2005 in Glasgow, UK. This was attended by most of the existing committee members with some additional invited participants (Table 1). The aims of this meeting were to facilitate the inclusion of new species onto the database, to discuss extension, improvement and funding of the database, and to address a number of nomenclature issues raised at the previous workshop.