Blood levels of long-chain n-3 fatty acids and the risk of sudden death.
Blood levels of long-chain n-3 fatty acids and the risk of sudden death.
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DOI：
10.1056/nejmoa012918
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发表时间：
2002-04-11
影响因子：
158.5
通讯作者：
Ma, J
中科院分区：
文献类型：
--
作者：
Albert, CM;Campos, H;Ma, J
背景资料：实验数据表明，在鱼类中发现的长链n-3多不饱和脂肪酸具有抗心律失常的特性，一项随机试验表明，n-3脂肪酸的膳食补充剂可能会降低心肌梗死幸存者猝死的风险。长链n-3脂肪酸是否也与那些没有心血管疾病史的人的猝死风险有关尚不清楚。方法：我们对在医师健康研究中随访长达17年的表面健康男性进行了前瞻性、巢式病例对照分析。采用气液色谱法对94例以猝死为首发表现的心血管疾病患者和184例年龄和吸烟状况与之匹配的对照者的血液进行脂肪酸成分分析。在校正潜在混杂因素之前，长链n-3脂肪酸的基线血液水平与猝死风险呈负相关，（趋势P = 0.004）和调整后（趋势P = 0.007）。与血液中长链n-3脂肪酸水平处于最低四分位数的男性相比，血液中长链n-3脂肪酸水平处于第三四分位数的男性发生猝死的相对风险明显较低（调整后的相对风险，0.28; 95%置信区间，0.09至0.87）和第四个四分位数（校正相对风险，0.19; 95%可信区间，0.05 ~ 0.71）结论：在没有心血管疾病证据的男性中，鱼类中发现的n-3脂肪酸与猝死风险降低密切相关。
Background: Experimental data suggest that long-chain n-3 polyunsaturated fatty acids found in fish have antiarrhythmic properties, and a randomized trial suggested that dietary supplements of n-3 fatty acids may reduce the risk of sudden death among survivors of myocardial infarction. Whether long-chain n-3 fatty acids are also associated with the risk of sudden death in those without a history of cardiovascular disease is unknown.Methods: We conducted a prospective, nested case-control analysis among apparently healthy men who were followed for up to 17 years in the Physicians' Health Study. The fatty-acid composition of previously collected blood was analyzed by gas-liquid chromatography for 94 men in whom sudden death occurred as the first manifestation of cardiovascular disease and for 184 controls matched with them for age and smoking status.Results: Base-line blood levels of long-chain n-3 fatty acids were inversely related to the risk of sudden death both before adjustment for potential confounders (P for trend = 0.004) and after such adjustment (P for trend = 0.007). As compared with men whose blood levels of long-chain n-3 fatty acids were in the lowest quartile, the relative risk of sudden death was significantly lower among men with levels in the third quartile (adjusted relative risk, 0.28; 95 percent confidence interval, 0.09 to 0.87) and the fourth quartile (adjusted relative risk, 0.19; 95 percent confidence interval, 0.05 to 0.71).Conclusions: The n-3 fatty acids found in fish are strongly associated with a reduced risk of sudden death among men without evidence of prior cardiovascular disease.