Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female
Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female
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DOI：
10.1098/rspb.2009.1236
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发表时间：
2010-01-07
影响因子：
4.7
通讯作者：
Shirras, Alan D.
中科院分区：
文献类型：
--
作者：
Isaac, R. Elwyn;Li, Chenxi;Shirras, Alan D.
静止，或类似睡眠的状态，是无脊椎动物和脊椎动物类群的动物日常生活中常见的重要特征，这表明睡眠出现在动物进化的早期。最近，黑腹果蝇已被证明是一个相关的和强大的模型，用于睡眠行为的遗传分析。D.黑腹果蝇是两性异形的，雌性在白天的睡眠时间比雄性少得多，可能是因为繁殖的成功需要雌性更大的觅食活动以及寻找产卵地点。然而，这种睡眠的丧失和运动活动的增加将增加雌性动物遭受环境和捕食者危害的风险。在这项研究中，我们表明，处女女性可以尽量减少这种风险，表现得像男性一样，延长下午的“午睡”。交配导致雌性失去70%的白天睡眠，变得更加活跃。这种行为在交配后至少持续8天，如果交配的雄性缺乏通常存在于精液中的性肽（SP），这种行为就会消失。我们的研究结果表明，SP是分子开关，促进交配后的女性觉醒，增加觅食和产卵活动兼容的行为变化。由SP依赖性睡眠剥夺引起的压力可能是雄性附属腺产品的毒性副作用的重要贡献，已知这些副作用会减少交配后雌性的寿命。
Quiescence, or a sleep-like state, is a common and important feature of the daily lives of animals from both invertebrate and vertebrate taxa, suggesting that sleep appeared early in animal evolution. Recently, Drosophila melanogaster has been shown to be a relevant and powerful model for the genetic analysis of sleep behaviour. The sleep architecture of D. melanogaster is sexually dimorphic, with females sleeping much less than males during day-time, presumably because reproductive success requires greater foraging activity by the female as well as the search for egg-laying sites. However, this loss of sleep and increase in locomotor activity will heighten the risk for the female from environmental and predator hazards. In this study, we show that virgin females can minimize this risk by behaving like males, with an extended afternoon 'siesta'. Copulation results in the female losing 70 per cent of day-time sleep and becoming more active. This behaviour lasts for at least 8 days after copulation and is abolished if the mating males lack sex peptide (SP), normally present in the seminal fluid. Our results suggest that SP is the molecular switch that promotes wakefulness in the post-mated female, a change of behaviour compatible with increased foraging and egg-laying activity. The stress resulting from SP-dependent sleep deprivation might be an important contribution to the toxic side-effects of male accessory gland products that are known to reduce lifespan in post-mated females.