The association between atypical adenomatous hyperplasia and primary lung cancer.
The association between atypical adenomatous hyperplasia and primary lung cancer.
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非典型腺瘤增生与原发性肺癌之间的关联。
DOI：
10.1054/bjoc.2000.1317
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发表时间：
2000-09
影响因子：
8.8
通讯作者：
Kerr KM
中科院分区：
文献类型：
--
作者：
Chapman AD;Kerr KM
非典型腺瘤样增生（AAH）被认为是肺外周腺瘤 - 癌序列中的腺瘤。从1989年到1998年，我们对因癌症切除的肺组织进行了系统性、前瞻性的AAH搜索。在554例原发性肺癌患者中，有67例（12.1%）发现了AAH（男性患者中为9.2%，女性患者中为19.0%）。在患有腺癌的肺组织中发现AAH的频率（23.2%）高于大细胞未分化癌（12.5%）或鳞状细胞癌（3.3%）。患有腺癌的女性中发现AAH的比例（30.2%）高于患有腺癌的男性（18.8%）。每个患者的AAH数量从1到42个不等，更多患者的AAH数量较少，尽管有12名患者有6个或更多的AAH病灶。在患有腺癌的肺组织中往往发现更多数量的AAH。67例患有AAH和原发性肺癌的患者中有10例（15%）患有多原发癌（范围为2 - 6个），且均为腺癌。在没有AAH的肺肿瘤切除术中，同时性癌症很少见。在所有癌症分期以及仅在I期疾病中，患有AAH的患者与未患AAH的患者在术后生存率方面没有差异。这项研究为非典型腺瘤样增生与原发性肺腺癌之间的紧密联系提供了证据，并支持了AAH/腺瘤 - 癌假说。© 2000癌症研究运动
Atypical adenomatous hyperplasia (AAH) has been suggested as the adenoma in an adenoma–carcinoma sequence in the lung periphery. From 1989–1998, we undertook a systematic, prospective search for AAH in lungs resected for cancer. AAH was found in 67 of 554 patients (12.1%) with primary lung carcinoma (9.2% in male patients and 19.0% in females). AAH was found in lungs bearing adenocarcinoma (23.2%) more frequently than with large cell undifferentiated carcinoma (12.5%) or squamous carcinoma (3.3%). A greater percentage of females with adenocarcinoma had AAH (30.2%) than did males with adenocarcinoma (18.8%). Numbers of AAH ranged from 1–42 per patient and more patients had small numbers of AAH, although 12 patients had 6 or more AAH foci. Larger numbers of AAH tended to be found in adenocarcinoma-bearing lungs. Ten of the 67 patients with AAH and primary lung carcinoma (15%) had multiple primary cancers (range 2–6), all of which were adenocarcinoma. Synchronous cancers were rare in lung tumour-bearing resections without AAH. Patients with AAH show no difference in post-operative survival to those without, for all stages of carcinoma and for Stage I disease alone. This study provides evidence for a strong association between atypical adenomatous hyperplasia and primary lung adenocarcinoma and lends weight to the AAH/adenoma-carcinoma hypothesis. © 2000 Cancer Research Campaign
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