Orbital Infarction due to Sickle Cell Disease without Orbital Pain.
Orbital Infarction due to Sickle Cell Disease without Orbital Pain.
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DOI：
10.1155/2016/5867850
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kumar KS
中科院分区：
文献类型：
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作者：
McBride CL;Mai KT;Kumar KS
镰状细胞病是一种血红蛋白病，其导致阵发性小动脉闭塞和可在多个组织中显现的组织梗塞。这些梗塞危机很少出现在骨眼眶中。眼眶梗塞通常表现为急性发作的眼眶周围压痛、肿胀、红斑和疼痛。软组织肿胀可导致眼球突出和眼外运动减弱。镰状细胞性眼眶梗塞的快速诊断至关重要，因为这是一种潜在威胁视力的疾病。由于所呈现的物理和放射学结果模仿了各种感染和创伤过程，因此可能会延迟诊断。我们描述了一位患有镰状细胞性眼眶危象但没有疼痛的患者。该病例凸显了对患有已知镰状细胞病或在美国境外出生的非洲裔患者保持高度怀疑的重要性，这些患者在血红蛋白病筛查并不常规的地区，即使表现并不典型。
Sickle cell disease is a hemoglobinopathy that results in paroxysmal arteriolar occlusion and tissue infarction that can manifest in a plurality of tissues. Rarely, these infarcted crises manifest in the bony orbit. Orbital infarction usually presents with acute onset of periorbital tenderness, swelling, erythema, and pain. Soft tissue swelling can result in proptosis and attenuation of extraocular movements. Expedient diagnosis of sickle cell orbital infarction is crucial because this is a potentially sight-threatening entity. Diagnosis can be delayed since the presentation has physical and radiographic findings mimicking various infectious and traumatic processes. We describe a patient who presented with sickle cell orbital crisis without pain. This case highlights the importance of maintaining a high index of suspicion in patients with known sickle cell disease or of African descent born outside the United States in a region where screening for hemoglobinopathy is not routine, even when the presentation is not classic.