Palladium(II)-catalyzed cyclization of urethanes and total synthesis of 1-deoxymannojirimycin.
Palladium(II)-catalyzed cyclization of urethanes and total synthesis of 1-deoxymannojirimycin.
复制标题
钯 (II) 催化的氨基甲酸酯环化和 1-脱氧甘露尻霉素的全合成。
DOI：
10.1002/chin.200045239
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发表时间：
2000
期刊：
影响因子：
5.2
通讯作者：
Y. Hirai
中科院分区：
文献类型：
--
作者：
H. Yokoyama;K. Otaya;H. Kobayashi;M. Miyazawa;S. Yamaguchi;Y. Hirai
衍生自D-甘露醇的氨基甲酸酯8经钯(II)催化环化，得到具有优异非对映选择性的环状化合物9。在这些转化过程中，Pd(II) 物质不会被还原，因此催化剂可以循环利用而无需再氧化。环加合物9被转化为1-脱氧甘露尻霉素。
The palladium(II)-catalyzed cyclization of the urethane 8, which was derived from D-mannitol, gave the cyclic compound 9 with excellent diastereoselectivity. During these transformations, the Pd(II) species are not reduced and thus the catalyst can recycle without its reoxidation. The cycloadduct 9 was converted to 1-deoxymannojirimycin.