Inflammation as a possible link between coronary and carotid plaque instability
Inflammation as a possible link between coronary and carotid plaque instability
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DOI：
10.1161/01.cir.0000130786.28008.56
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发表时间：
2004-06-29
期刊：
影响因子：
37.8
通讯作者：
Maseri, A
中科院分区：
文献类型：
--
作者：
Lombardo, A;Biasucci, LM;Maseri, A
背景：在急性冠脉综合征中，多发性复杂的狭窄、斑块裂缝和广泛的冠脉炎症是常见的。对缺血性脑血管疾病的研究也提示动脉粥样硬化斑块不稳定的系统性原因。方法和结果：对181例不稳定型心绞痛患者和92例稳定型心绞痛患者的颈动脉斑块超声特征进行了回顾性研究，并对67例不稳定型心绞痛患者和25例稳定型心绞痛患者的颈动脉斑块超声特征进行了前瞻性研究，同时检测了患者血清C反应蛋白水平。在回顾和前瞻性研究中，颈动脉斑块的患病率相似，在不稳定和稳定的冠状动脉患者中，颈动脉斑块的患病率均为-gt；%。不稳定组复杂的、可能不稳定的颈动脉斑块的发生率为23.2%，稳定组为3.2%(P
Background-Multiple complex stenoses, plaque fissures, and widespread coronary inflammation are common in acute coronary syndromes. A systemic cause of atherosclerotic plaque instability is also suggested by studies of ischemic cerebrovascular disease. We investigated the association between coronary and carotid plaque instability and the potential common causal role of inflammation.Methods and Results-The ultrasound characteristics of carotid plaques were evaluated retrospectively in patients scheduled for coronary bypass surgery, 181 with unstable and 92 with stable angina, and prospectively in a similar group of patients, 67 with unstable and 25 with stable angina, in whom serum C-reactive protein levels were also measured. The prevalence of carotid plaques was similar in the retrospective and prospective studies and >64% in both unstable and stable coronary patients. The prevalence of complex, presumably unstable carotid plaques was 23.2% in unstable versus 3.2% in stable patients (P