MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex
MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex
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DOI：
10.1371/journal.pone.0224175
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发表时间：
2019-10
期刊：
影响因子：
3.7
通讯作者：
K. Tamura;Takahiro Osada;Akitoshi Ogawa;Masaki Tanaka;A. Suda;Y. Shimo;N. Hattori;K. Kamagata;M. Hori;S. Aoki;Takahiro Shimizu;H. Enomoto;R. Hanajima;Y. Ugawa;S. Konishi
中科院分区：
文献类型：
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作者：
K. Tamura;Takahiro Osada;Akitoshi Ogawa;Masaki Tanaka;A. Suda;Y. Shimo;N. Hattori;K. Kamagata;M. Hori;S. Aoki;Takahiro Shimizu;H. Enomoto;R. Hanajima;Y. Ugawa;S. Konishi
重复经颅磁刺激（rTMS）在干预结束后几分钟到几小时内诱导皮层兴奋性的变化。然而，还没有精确地确定皮层可塑性在多大程度上在空间上占主导地位。最近的研究表明，rTMS诱导了“半球间”功能连通性的变化，即受刺激区域与对侧半球对称对应区域之间的静息状态功能连通性。在本研究中，四脉冲刺激（QPS）应用于左手初级运动皮层（M1）的食指表征，同时刺激线圈的位置由在线导航器持续监测。应用QPS后，进行静息状态功能磁共振成像，比较与QPS前的脑间功能连通性。在中央沟受刺激区域观察到一系列连通性变化。该簇在空间上从中心向外延伸约10毫米[半宽半高（HWHM）：约3毫米]，在深度上延伸约20毫米（HWHM：约7毫米）。对食指运动的定位扫描证实，大脑半球间连通性的变化簇在空间上与食指运动相关的激活重叠。这些结果表明，rTMS诱导的M1皮质可塑性在空间上是相对受限的，rTMS可以通过诱导受限皮质区域的神经可塑性来揭示与相邻小区域相关的功能解离。
Repetitive transcranial magnetic stimulation (rTMS) induces changes in cortical excitability for minutes to hours after the end of intervention. However, it has not been precisely determined to what extent cortical plasticity prevails spatially in the cortex. Recent studies have shown that rTMS induces changes in “interhemispheric” functional connectivity, the resting-state functional connectivity between the stimulated region and the symmetrically corresponding region in the contralateral hemisphere. In the present study, quadripulse stimulation (QPS) was applied to the index finger representation in the left primary motor cortex (M1), while the position of the stimulation coil was constantly monitored by an online navigator. After QPS application, resting-state functional magnetic resonance imaging was performed, and the interhemispheric functional connectivity was compared with that before QPS. A cluster of connectivity changes was observed in the stimulated region in the central sulcus. The cluster was spatially extended approximately 10 mm from the center [half width at half maximum (HWHM): approximately 3 mm] and was extended approximately 20 mm long in depth (HWHM: approximately 7 mm). A localizer scan of the index finger motion confirmed that the cluster of interhemispheric connectivity changes overlapped spatially with the activation related to the index finger motion. These results indicate that cortical plasticity in M1 induced by rTMS was relatively restricted in space and suggest that rTMS can reveal functional dissociation associated with adjacent small areas by inducing neural plasticity in restricted cortical regions.