Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs
Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs
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DOI：
10.1016/j.bmcl.2009.03.163
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发表时间：
2009-07-15
影响因子：
2.7
通讯作者：
Meijler, Michael M.
中科院分区：
文献类型：
--
作者：
Ganin, Hadas;Tang, Xu;Meijler, Michael M.
自诱导物-2（AI-2）被认为是一种通用的种间群体感应信号分子。我们已经合成了一组AI-2类似物，在C-2上的烷基取代具有小的增量变化，并评估它们作为两种不同细菌物种中的群体感应（QS）衰减剂的激动和拮抗潜力：铜绿假单胞菌和哈氏弧菌。出乎意料的是，发现几种类似物在哈维氏弧菌中起协同QS激动剂的作用，而这些类似物中的两种在铜绿假单胞菌中抑制QS。(C)2009爱思唯尔有限公司版权所有。
Autoinducer-2 (AI-2) has been suggested to serve as a universal interspecies quorum sensing signaling molecule. We have synthesized a set of AI-2 analogs with small incremental changes in alkyl substitution on C-2 and evaluated them for their agonistic and antagonistic potential as quorum sensing (QS) attenuators in two different bacterial species: Pseudomonas aeruginosa and Vibrio harveyi. Unexpectedly, several of the analogs were found to function as synergistic QS agonists in V. harveyi, while two of these analogs inhibit QS in P. aeruginosa. (C) 2009 Elsevier Ltd. All rights reserved.