In vivo detection of experimentally induced cortical dysgenesis in the adult rat neocortex using optical coherence tomography
In vivo detection of experimentally induced cortical dysgenesis in the adult rat neocortex using optical coherence tomography
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DOI：
10.1016/s0165-0270(97)00202-1
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发表时间：
1998-03-13
影响因子：
3
通讯作者：
Reitze, DH
中科院分区：
文献类型：
--
作者：
Roper, SN;Moores, MD;Reitze, DH
活体脑结构成像可以通过许多方法完成，包括MRI、超声和计算机断层扫描。每一种都提供了相对于其他的优点和缺点，但在常规应用中使用时，所有的空间分辨率都限于毫米级特征。光学相干层析成像（OCT）是一种利用光直接对活体组织成像的高分辨率成像技术。在这里，我们调查的潜在用途OCT结构成像的充分发展的哺乳动物大脑皮层。特别是，我们表明，OCT可以在体内检测新皮质和区分正常和异常的皮质解剖。我们提出了详细的光学相干断层扫描（OCT）观察正常和异常大鼠新皮层在体内获得的结果。比较组织学分析显示与OCT断层图像具有良好的相关性。(C)1998 Elsevier Science B.V.保留所有权利。
Imaging cerebral structure in vivo can be accomplished by many methods, including MRI, ultrasound, and computed tomography. Each offers advantages and disadvantages with respect to the others, but all are limited in spatial resolution to millimeter-scale features when used in routine applications. Optical coherence tomography (OCT) is a new, high resolution imaging technique which uses light to directly image living tissue. Here, we investigate the potential use of OCT for structural imaging of the fully developed mammalian cerebral cortex. In particular, we show that OCT can perform in vivo detection of neocortex and differentiate normal and abnormal cortical anatomy. We present the results of detailed optical coherence tomographic (OCT) observations of both normal and abnormal rat neocortex obtained in vivo. Comparative histologic analysis shows excellent correlation with the OCT tomograms. (C) 1998 Elsevier Science B.V. All rights reserved.