Bone substitutes: An update
Bone substitutes: An update
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DOI：
10.1016/j.injury.2005.07.029
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发表时间：
2005-11-01
影响因子：
2.5
通讯作者：
Tsiridis, E
中科院分区：
文献类型：
--
作者：
Giannoudis, PV;Dinopoulos, H;Tsiridis, E
自体移植被认为是理想的移植手术，提供骨诱导生长因子、成骨细胞和骨传导支架。然而，在供区发病率和移植物可获得性方面存在局限性。另一方面，同种异体移植有传播疾病的风险。合成的嫁接替代物缺乏骨诱导或成骨特性。复合移植物将支架特性与生物元素相结合，以刺激细胞增殖和分化，最终促进成骨。我们在此对临床上可用的骨移植和骨移植替代品作一综述。(C)2005爱思唯尔有限公司。保留所有权利。
Autograft is considered ideal for grafting procedures, providing osteoinductive growth factors, osteogenic cells, and an osteoconductive scaffold. Limitations, however, exist regarding donor site morbidity and graft availability. Allograft on the other hand, posses the risk of disease transmission. Synthetic graft substitutes Lack osteoinductive or osteogenic properties. Composite grafts combine scaffolding properties with biological elements to stimulate cell proliferation and differentiation and eventually osteogenesis. We present here an overview of bone grafts and graft substitutes available for clinical applications. (c) 2005 Elsevier Ltd. All rights reserved.