Distinct prognostic values of ALDH1 isoenzymes in breast cancer
Distinct prognostic values of ALDH1 isoenzymes in breast cancer
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DOI：
10.1007/s13277-014-2852-6
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发表时间：
2015-01
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影响因子：
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通讯作者：
Shaokun Wu;W. Xue;Xiaobo Huang;Xiaoli Yu;M. Luo;Ying Huang;Yimin Liu;Z. Bi;X. Qiu;S. Bai
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文献类型：
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作者：
Shaokun Wu;W. Xue;Xiaobo Huang;Xiaoli Yu;M. Luo;Ying Huang;Yimin Liu;Z. Bi;X. Qiu;S. Bai
乙醛脱氢酶1（ALDH1）又称乙醛脱氢酶1家族，由六种酶组成，在干细胞中高水平表达，参与干细胞功能的调节。在白血病和包括乳腺癌 (BC) 在内的一些实体瘤的干细胞群中发现 ALDH1 活性增加。然而，哪些 ALDH1 同工酶对 ALDH1 活性有贡献尚未确定。此外，个体 ALDH1 同工酶的预后价值尚不清楚。在当前的研究中，我们通过“Kaplan-Meier绘图仪”（KM绘图仪）数据库研究了ALDH1同工酶在BC患者中的预后价值，其中更新的基因表达数据和生存信息来自总共3455名BC患者。发现ALDH1A1信使RNA（mRNA）高表达与所有BC患者总生存期（OS）恶化相关。发现ALDH1A2和ALDH1L1mRNA高表达与所有 BC 患者更好的 OS 相关。未发现 ALDH1A3 和 ALDH1B1 mRNA 高表达与所有 BC 患者的 OS 相关。这些结果有力地支持了 ALDH1A1 只是 ALDH1 同工酶中预测 BC 患者生存不良的生物标志物。 ALDH1A1 可能是 BC 中 ALDH1 活性的主要贡献者，因为发现只有 ALDH1A1mRNA 高表达与所有 BC 患者的 OS 恶化显着相关。
Aldehyde dehydrogenase 1 (ALDH1), also known as aldehyde dehydrogenase 1 family, is composed of six enzymes that are expressed at high levels in stem cells and are involved in the regulation of stem cell function. Increased ALDH1 activity has been found in the stem cell populations of leukemia and some solid tumors including breast cancer (BC). However, which ALDH1’s isoenzymes are contributing to ALDH1 activity has not been determined. In addition, the prognostic value of individual ALDH1 isoenzyme is not clear. In the current study, we investigated the prognostic value of ALDH1 isoenzymes in BC patients through “the Kaplan-Meier plotter” (KM plotter) database, in which updated gene expression data and survival information are from a total of 3455 BC patients.ALDH1A1messenger RNA (mRNA) high expression was found to be correlated to worsen overall survival (OS) for all BC patients.ALDH1A2andALDH1L1mRNA high expressions were found to be correlated to better OS for all BC patients. Both ofALDH1A3andALDH1B1mRNA high expressions were not found to be correlated to OS for all BC patients. These results strongly support that ALDH1A1 was only a biomarker for predicting poor survival of BC patients among ALDH1 isoenzymes. ALDH1A1 might be a major contributor of ALDH1 activity in BC, since onlyALDH1A1mRNA high expression was found to be significantly correlated to worsen OS for all BC patients.