CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA.
CORRELATIONS BETWEEN CHOROIDAL STRUCTURES AND VISUAL FUNCTIONS IN EYES WITH RETINITIS PIGMENTOSA.
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DOI：
10.1097/iae.0000000000002285
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发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Sakamoto T
中科院分区：
文献类型：
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作者：
Egawa M;Mitamura Y;Niki M;Sano H;Miura G;Chiba A;Yamamoto S;Sonoda S;Sakamoto T
作者报告了100例视网膜色素变性患者和60例正常对照者的增强深度成像光学相干断层扫描图像的二值化所确定的脉络膜内、外结构的变化，以及视网膜色素变性患者脉络膜内结构与视功能之间的显著相关性。目的探讨视网膜色素变性（retinitis pigmentosa，RP）患者增强深度成像光学相干断层扫描（optical coherence tomography，OCT）图像中脉络膜结构的变化及其与视功能的关系。使用ImageJ对100只典型RP眼和60只年龄、性别和眼轴长度匹配的正常眼的增强深度成像光学相干断层扫描图像进行二值化。测量宽度为1，500 µm的内外中心凹下脉络膜的横截面管腔和基质面积。脉络膜内层包括脉络膜毛细血管层和中血管层，脉络膜外层包括大血管层。在脉络膜内层，RP的管腔面积和管腔/脉络膜总面积比值（L/C比值）显著小于对照组（P = 0.010，P < 0.001），而基质面积无显著差异（P = 0.114）。校正眼轴长度、年龄和性别后，RP患者的内脉络膜L/C比值与最佳矫正视力、平均偏差、中心凹敏感度、椭圆体区宽度和中心凹厚度显著相关（均P < 0.005）。脉络膜内部结构与视功能及视网膜结构的相关性表明，脉络膜结构的改变与RP的进展有关。
The author report the structural changes in the inner and outer choroid determined by the binarization of enhanced depth imaging optical coherence tomographic images in 100 eyes with retinitis pigmentosa compared with 60 normal controls and significant correlations between the inner choroidal structures and visual functions in the eyes with retinitis pigmentosa. To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length–matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer. In the inner choroid, the luminal area and the ratio of luminal/total choroidal area (L/C ratio) were significantly smaller in RP than in controls (P = 0.010, P < 0.001, respectively), whereas the stromal area was not significantly different (P = 0.114). The inner choroidal L/C ratio was significantly correlated with the best-corrected visual acuity, mean deviation, foveal sensitivity, width of the ellipsoid zone, and central foveal thickness in RP after adjusting for the axial length, age, and sex (all P < 0.005). The significant correlations between the inner choroidal structures and the visual functions and retinal structures indicate that the choroidal structures are altered in association with the progression of RP.