Flexible specificity of memory in Drosophila depends on a comparison between choices.
Flexible specificity of memory in Drosophila depends on a comparison between choices.
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DOI：
10.7554/elife.80923
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发表时间：
2023-06-15
期刊：
影响因子：
7.7
通讯作者：
Turner GC
中科院分区：
文献类型：
--
作者：
Modi MN;Rajagopalan AE;Rouault H;Aso Y;Turner GC
记忆引导着各种环境下的行为，因此必须既具有足够的特殊性，又具有普遍性。过于特定的内存即使在稍微不同的环境中也是无用的，而过于通用的内存可能会导致次优选择。动物成功地学会了区分非常相似的刺激和通过线索进行归纳。果蝇不会形成在特异性和普遍性之间取得平衡的记忆，而是可以根据可用的选项灵活地将给定的刺激分类为不同的组。我们想知道这种灵活性是如何在果蝇的学习和记忆途径中表现出来的。研究表明，神经元活动和行为的灵活分类取决于感知刺激的顺序和身份。我们的研究结果确定了果蝇灵活刺激分类的神经关联。
Memory guides behavior across widely varying environments and must therefore be both sufficiently specific and general. A memory too specific will be useless in even a slightly different environment, while an overly general memory may lead to suboptimal choices. Animals successfully learn to both distinguish between very similar stimuli and generalize across cues. Rather than forming memories that strike a balance between specificity and generality, Drosophila can flexibly categorize a given stimulus into different groups depending on the options available. We asked how this flexibility manifests itself in the well-characterized learning and memory pathways of the fruit fly. We show that flexible categorization in neuronal activity as well as behavior depends on the order and identity of the perceived stimuli. Our results identify the neural correlates of flexible stimulus-categorization in the fruit fly.