INHIBITION OF TRANSMITTER RELEASE FROM SYMPATHETIC-NERVE ENDINGS BY OMEGA-CONOTOXIN
INHIBITION OF TRANSMITTER RELEASE FROM SYMPATHETIC-NERVE ENDINGS BY OMEGA-CONOTOXIN
复制标题
DOI：
10.1111/j.1440-1681.1989.tb01568.x
复制
发表时间：
1989-04-01
影响因子：
2.9
通讯作者：
ZIOGAS, J
中科院分区：
文献类型：
--
作者：
BROCK, JA;CUNNANE, TC;ZIOGAS, J
1.采用机械和电生理相结合的记录技术，研究了钙通道阻滞剂ω-芋螺毒素对豚鼠输精管交感神经效应的影响。电场刺激引起的双相收缩可被ω-芋螺毒素(10-100nmol/L)不可逆地阻断。电诱发的兴奋性连接电位和电流可被ω-芋螺毒素(10-100nmol/L)不可逆阻断。自发兴奋性连接电位和电流不受此处理的影响。ω-芋螺毒素不能阻断冲动在神经末梢的传播。然而，在四个实验中的三个实验中，ω-芋螺毒素导致神经末梢冲动的大小减小。这些发现支持这样一种说法，即共芋螺毒素通过干扰去极化-分泌耦合而预先作用于交感神经效应器。
1. The effects of the calcium channel blocker, ω‐conotoxin, on sympathetic neuroeffector function in the guinea‐pig vas deferens have been investigated using a combination of mechanical and electrophysiological recording techniques.2. Diphasic contractions evoked by electrical field stimulation were irreversibly abolished by ω‐conotoxin (10–100 nmol/L).3. Electrically evoked excitatory junction potentials and currents were irreversibly blocked by ω‐conotoxin (10–100 nmol/L). Spontaneous excitatory junction potentials and currents were unaffected by this treatment.4. ω‐Conotoxin did not block impulse propagation in the nerve terminals. However, in three of four experiments ω‐conotoxin caused a decrease in the size of the nerve terminal impulse.5. These findings support the suggestion the co‐conotoxin acts prejunctionally to inhibit sympathetic neuroeffector by interfering with depolarization‐secretion coupling.