Immunosuppressive activity of hymenistatin I
Immunosuppressive activity of hymenistatin I
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DOI：
10.1016/0196-9781(95)02123-x
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发表时间：
1996-01-01
期刊：
影响因子：
3
通讯作者：
Siemion, IZ
中科院分区：
文献类型：
--
作者：
Cebrat, M;Wieczorek, Z;Siemion, IZ
采用固相多肽合成法合成了环八肽[c-（-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-）]膜蛋白抑制素I（Hymenistatin I，HS-I），并对其体液免疫和细胞免疫抑制活性进行了研究。在产生各种细胞因子的细胞系上测试肽活性。结果与著名的免疫抑制剂环孢菌素A（CsA）的活性进行了比较。结果发现，hymenistatin I发挥免疫抑制作用（在体液和细胞免疫应答中）与CsA相当。HS-I和CsA对细胞因子产生的影响的比较表明，与免疫系统的相互作用的机制是基本上不同的两种化合物测试。
Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The results are compared with the activity of the well-known immunosuppressive agent cyclosporin A (CsA). It was found that hymenistatin I exerts immunosuppressive effect (both in the humoral and cellular immune responses) comparable with that of CsA. Comparison of the influence of HS-I and CsA on cytokines production suggests that the mechanisms of the interaction with the immunological system are substantially different for the two compounds tested.