A chiral phenoxyamine magnesium catalyst for the enantioselective hydroamination/cyclization of aminoalkenes and intermolecular hydroamination of vinyl arenes.
A chiral phenoxyamine magnesium catalyst for the enantioselective hydroamination/cyclization of aminoalkenes and intermolecular hydroamination of vinyl arenes.
复制标题
DOI：
10.1002/anie.201105079
复制
发表时间：
2012-01
影响因子：
--
通讯作者：
Xiaoming Zhang;T. Emge;K. Hultzsch
中科院分区：
文献类型：
--
作者：
Xiaoming Zhang;T. Emge;K. Hultzsch
要是格林纳知道就好了！手性镁络合物可在低至−20 °C的温度下高效催化氨基烯烃的分子内氢胺化/环化反应，对映选择性高达93%ee。该体系的高活性还允许吡咯烷和苄胺与乙烯基芳烃的催化分子间反马氏加成反应。
If Grignard had only known! A chiral magnesium complex catalyzes the intramolecular hydroamination/cyclization of aminoalkenes with high efficiency at temperatures as low as −20 °C and enantioselectivities as high as 93 % ee. The high activity of this system also allows the catalytic intermolecular anti-Markovnikov addition of pyrrolidine and benzylamine to vinyl arenes.