Shared Biologic Pathways Between Alzheimer Disease and Major Depression: A Systematic Review of MicroRNA Expression Studies
Shared Biologic Pathways Between Alzheimer Disease and Major Depression: A Systematic Review of MicroRNA Expression Studies
复制标题
DOI：
10.1016/j.jagp.2016.07.017
复制
发表时间：
2016-10-01
影响因子：
7.2
通讯作者：
Diniz, Breno S.
中科院分区：
文献类型：
--
作者：
Mendes-Silva, Ana Paula;Pereira, Kelly Silva;Diniz, Breno S.
目的：重性抑郁症（MDD）和阿尔茨海默病（AD）之间的临床流行病学关系表明，它们可能具有共同的神经生物学异常。方法：作者进行了系统的回顾，并确定了AD和MDD中异常表达的microRNA。确定了每种疾病中microRNA调控的模式、每种microRNA调控的基因以及这些基因调控的生物学过程和途径。结果如下：74种microRNA在AD中异常表达，30种在MDD中异常表达; 7种在两种疾病中常见（hsa-let-7 f-5 p、hsa-miR-664 a-3 p、hsa-miR-361- 5 p、hsa-let-7 g-5 p、hsa-let-7 d-5 p、hsa-miR-191- 5 p、hsa-miR-26 b-5 p）。这些microRNA与45个经验证的基因相互作用，并且由它们调节的主要生物学途径和过程是蛋白质稳定控制、基因组完整性的维持、转录活性的调节、免疫炎症控制和神经营养支持。结论：目前的研究结果表明，基因组的完整性，蛋白质稳态控制，免疫炎症调节和神经营养支持的维护是这些条件之间的关键神经生物学联系。一个全面的假设模型之间的相互作用MDD，老化，AD的发展。
Objective: The clinical-epidemiological relationship between major depressive disorder (MDD) and Alzheimer disease (AD) suggests that they may share common neurobiologic abnormalities. Methods: The authors conducted a systematic review and identified microRNAs abnormally expressed in both AD and MDD. The pattern of microRNA regulation in each disorder and the genes regulated by each microRNA and the biologic processes and pathways regulated by these genes were identified. Results: Seventy-four microRNAs were abnormally expressed in AD and 30 in MDD; 7 were common for both disorders (hsa-let-7f-5p, hsa-miR-664a-3p, hsa-miR-361-5p, hsa-let-7g-5p, hsa-let-7d-5p, hsa-miR-191-5p, hsa-miR-26b-5p). These microRNAs interact with 45 validated genes, and the main biologic pathways and processes regulated by them were proteostasis control, maintenance of genomic integrity, regulation of transcriptional activity, immune-inflammatory control, and neurotrophic support. Conclusion: The current results suggest that the maintenance of genomic integrity, proteostasis control, immune-inflammatory regulation, and neurotrophic support are key neurobiologic links between these conditions. A comprehensive hypothetical model for the interaction between MDD, aging, and the development of AD is provided.