Association of birth weight with osteoporosis and osteoarthritis in adult twins
Association of birth weight with osteoporosis and osteoarthritis in adult twins
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DOI：
10.1093/rheumatology/keg227
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发表时间：
2003-06-01
期刊：
影响因子：
5.5
通讯作者：
Spector, TD
中科院分区：
文献类型：
--
作者：
Antoniades, L;MacGregor, AJ;Spector, TD
目标.双胞胎研究提供了一个独特的机会来研究出生体重与成年生活表型的关联，这种设计自然地考虑了母体因素和一系列早期环境因素，这可能会使这种关联产生偏差。在这项研究中，我们探讨了出生体重与骨质疏松症（OP）和骨关节炎（OA）的关系，在一个大的全国性队列的女性双胞胎。双胞胎（n=4008）报告的出生体重之间的配对差异与以下因素的相关性进行了检查：（i）使用线性回归分析腰椎、髋关节和前臂骨矿物质密度（BMD）和骨矿物质含量（BMC）的配对差异;（ii）使用匹配的logistic回归分析手部、髋关节和膝关节放射学疾病不一致的配对骨关节炎状态。考虑身高和体重的混杂影响。双胞胎的平均年龄为47.5 ± 12.3岁。出生体重的配对间差异与脊柱（P=0.047）、全髋（P=0.016）和股骨颈（P
Objectives. Twin studies present a unique opportunity to examine the association of birth weight with adult life phenotypes in a design that naturally accounts for maternal factors and a range of early environmental factors, which might potentially bias the association. In this study, we explored the association of birth weight with osteoporosis (OP) and osteoarthritis (OA), in a large national cohort of female twins.Methods. Intra-pair differences between the reported birth weight of the twins (n=4008) were examined for an association with: (i) intra-pair differences in bone mineral density (BMD) and bone mineral content (BMC) at the lumbar spine, hip and forearm using linear regression; and (ii) osteoarthritis status in pairs discordant for radiographic disease at the hand, hip and knee using matched logistic regression. The confounding influences of height and weight were taken into account.Results. The mean age of the twins was 47.5+/-12.3 yr. Intra-pair differences in birth weight were significantly associated with BMD at the spine (P=0.047), total hip (P=0.016) and femoral neck (P