FC-SPECIFIC RETICULOENDOTHELIAL CLEARANCE IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND GLOMERULONEPHRITIS
FC-SPECIFIC RETICULOENDOTHELIAL CLEARANCE IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND GLOMERULONEPHRITIS
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DOI：
10.1016/s0272-6386(84)80047-5
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发表时间：
1984-01-01
影响因子：
13.2
通讯作者：
WOODROFFE, AJ
中科院分区：
文献类型：
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作者：
BANNISTER, KM;HAY, J;WOODROFFE, AJ
在对照组（n = 11）和免疫复合物（IC）肾小球肾炎（n = 22）和系统性红斑狼疮（SLE）肾炎（n = 10）患者中测定fc特异性网状内皮（R-E）清除率。清除（t1/2）依赖于通过携带IgG分子Fc部分受体的固定脾巨噬细胞清除带有51铬标记并被抗d IgG致敏的自体红细胞。在具有和不具有HLA-B8， DR3单倍型的正常个体之间，清除率存在显著差异。SLE患者存在明显的清除缺陷（8/10），t1/2与循环IC水平相关。6/11 IgA肾病或过敏性紫癜患者和4/11膜性肾病（MN）患者也存在清除延迟。在这些疾病中，循环IC水平与t1/2无相关性。这些患者的清除缺陷与HLA-B8， DR3单倍型的存在无关。这项研究表明，一些IC型肾小球肾炎患者有缺陷的fc介导的清除，这似乎不是IC阻断的继发原因。
Fc-specific reticulo-endothelial (R-E) clearance was determined in control subjects (n = 11) and in patients with immune complex (IC) glomerulonephritis (n = 22) and systemic lupus erythematosus (SLE) nephritis (n = 10). Clearance (t1/2) depended on the removal of autologous erythrocytes labeled with51chromium and sensitized with anti-D IgG by fixed splenic macrophages bearing receptors for the Fc portion of the IgG molecule. A significant difference in clearance rates was demonstrated between normal individuals with and without the HLA-B8, DR3 haplotype. Marked clearance defects were found in SLE (8/10), and t1/2 correlated with the levels of circulating IC. Delayed clearance was also observed in 6/11 patients with IgA nephropathy or Henoch-Schonlein purpura and in 4/11 patients with membranous nephropathy (MN). No correlation was found between circulating IC levels and t1/2 in these diseases. Clearance defects in these patients did not correlate with the presence of the HLA-B8, DR3 haplotype. This study demonstrates that some patients with IC glomerulonephritis have defective Fc-mediated clearance that does not appear to be secondary to IC blockade.