Growth, ageing and scaling laws of coronary arterial trees
Growth, ageing and scaling laws of coronary arterial trees
复制标题
冠状动脉树的生长、衰老和缩放规律。
DOI：
10.1098/rsif.2015.0830
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发表时间：
2015-12-06
影响因子：
3.9
通讯作者：
Huo, Yunlong
中科院分区：
文献类型：
--
作者：
Chen, Xi;Niu, Pei;Huo, Yunlong
尽管众所周知的血管系统的设计原则，目前还不清楚是否血管动脉树在正常生长和老化过程中，在一个给定的物种服从一些缩放约束。通过对不同月龄（1周至8月龄以上）小鼠冠状动脉树的显微CT测量，发现冠状动脉树的长度-体积比例律（L-c = K长度-体积）中的比例系数为3/4，但与年龄相关。V-c（3/4）; L-c是冠长，V-c是冠体积，K长度-体积是在正常生长和老化过程中的年龄相关比例系数。恒定的3/4指数代表自相似的分形状分支模式（即调节物种内维管树发育的基本机制），而年龄相关的比例系数分别表征正常生长或衰老期间维管树的结构生长或再吸收。这项研究增强了对血管结构和功能的年龄相关变化的理解。
Despite the well-known design principles of vascular systems, it is unclear whether the vascular arterial tree obeys some scaling constraints during normal growth and ageing in a given species. Based on the micro-computed tomography measurements of coronary arterial trees in mice at different ages (one week to more than eight months), we show a constant exponent of 3/4, but age-dependent scaling coefficients in a length-volume scaling law (L-c = Klength-volume . V-c(3/4); L-c is the crown length, V-c is the crown volume, Klength-volume is the age-dependent scaling coefficient) during normal growth and ageing. The constant 3/4 exponent represents the self-similar fractal-like branching pattern (i.e. basic mechanism to regulate the development of vascular trees within a species), whereas the age-dependent scaling coefficients characterize the structural growth or resorption of vascular trees during normal growth or ageing, respectively. This study enhances the understanding of age-associated changes in vascular structure and function.