Age-related decline of human interferon alpha and interferon gamma production
Age-related decline of human interferon alpha and interferon gamma production
复制标题
人干扰素α和干扰素γ产生与年龄相关的下降
DOI：
10.1007/bf00320399
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
F. Deinhardt
中科院分区：
文献类型：
--
作者：
J. Abb;H. Abb;F. Deinhardt
本文研究了供者年龄对人外周血单个核细胞体外产生干扰素（IFN）α和IFN γ的影响。结果表明，年龄相关的能力下降，合成和分泌抗病毒活性。与年轻受试者（< 50岁）相比，老年受试者（> 50岁）单核细胞培养物中病毒诱导的IFN α和凝集素诱导的IFN γ产量显著降低。观察到的IFN产生的不足可能涉及老年人对病毒感染和恶性疾病的易感性增加。
SummaryThe influence of donor age on the production of interferon (IFN) alpha and IFN gamma by human peripheral blood mononuclear cells in vitro has been studied. The results demonstrate an age-related decline of the capacity to synthesize and secrete antiviral activity. Yields of virus-induced IFN alpha and lectin-induced IFN gamma were significantly decreased in mononuclear cell cultures from older subjects (> 50 years) when compared to those of younger subjects (< 50 years). The observed deficiency of IFN production may be involved in the increased susceptibility of aged humans to viral infections and malignant diseases.