Association of maximum weight with hyperuricemia risk: a retrospective study of 21,414 Chinese people.
Association of maximum weight with hyperuricemia risk: a retrospective study of 21,414 Chinese people.
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最大体重与高尿酸血症风险的关系：对 21,414 名中国人的回顾性研究
DOI：
10.1371/journal.pone.0051186
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ji Q
中科院分区：
文献类型：
--
作者：
Gao B;Zhou J;Ge J;Zhang Y;Chen F;Lau WB;Wan Y;Zhang N;Xing Y;Wang L;Fu J;Li X;Jia H;Zhao X;Ji Q
背景 肥胖已被证明与血清尿酸 (SUA) 升高有关；然而，关于最大体重或最大体重波动与尿酸浓度之间的关系知之甚少。通过回顾性方法，我们确定了最大体重与 SUA 风险的关联。方法对2007年8月中国全国糖尿病和代谢紊乱研究的21,414名参与者（8,630名男性和12,784名女性）的数据进行分析，包括生活习惯、血液生化分析和自我报告的最大体重等参数。结果 SUA 升高的受试者具有一系列人口统计学特征。在调整年龄、性别、教育程度、吸烟、饮酒、体力活动、腰臀比、身高、eGFR（评估肾小球滤过率）和利尿剂使用后，多变量逻辑回归模型表明最大体重与 SUA 水平升高的风险增加相关（P<0.001）。最大体重持续时间与 SUA 水平升高的风险降低相关（P<0.001）。减肥时间与 SUA 水平降低增加的风险之间存在显着相关性（P<0.001）。此外，我们的数据表明，从最大体重开始减重的程度是导致 SUA 水平降低风险增加的另一个重要因素（P<0.001）。最后，ROC 曲线分析显示曲线下面积为 0.661（95% CI，0.647-0.674），最大体重与高尿酸血症的相关性具有统计学意义（P<0.001）。结论 最大体重是中国人群尿酸水平升高的重要危险因素，可能作为提示高尿酸血症的新临床指标。控制最大体重，将体重控制在适当范围，保持体重稳定，可能有利于降低高尿酸血症的风险。
Background Obesity has been demonstrated to be associated with increased serum uric acid (SUA); however, little is known regarding the relationship between maximum weight, or maximum weight fluctuation, and uric acid concentration. Through retrospective means, we determined the association of maximum weight with SUA risk. Methods Data of 21,414 participants (8,630 males and 12,784 females) from the 2007-8 China National Diabetes and Metabolic Disorders Study were analyzed for parameters including lifestyle habits, biochemical blood analysis and self-reported maximum weight. Results Elevated SUA subjects shared a cluster of demographic features. After adjustment for age, gender, education, smoking, drinking, physical activity, WHR, height, eGFR(evaluate glomerular filtration rate), and diuretic usage, multivariate logistic regression models demonstrated maximum weight was associated with increased risk of elevated SUA level (P<0.001). Duration of maximum weight was related with decreased risk of elevated SUA level (P<0.001). There was a significant correlation between time of weight loss and risk of increased SUA level reduction (P<0.001). Furthermore, our data indicated that the degree of weight loss from maximum weight was another important factor for the risk of increased SUA level reduction (P<0.001). Finally, ROC curve analysis revealed area under the curve was 0.661 (95% CI, 0.647-0.674), statistically significant for maximum weight association with hyperuricemia (P<0.001). Conclusions Maximum weight is a strong risk factor for increased uric acid level in the Chinese population, which might serve as a novel clinical indicator suggesting hyperuricemia. Controlling maximum weight, keeping weight to the appropriate range, and maintaining the stable weight may be conducive for decreasing risk of hyperuricemia.