ABCD2 Score Predicts Severity Rather Than Risk of Early Recurrent Events After Transient Ischemic Attack
ABCD2 Score Predicts Severity Rather Than Risk of Early Recurrent Events After Transient Ischemic Attack
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DOI：
10.1161/strokeaha.109.570010
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发表时间：
2010-05-01
期刊：
影响因子：
8.3
通讯作者：
Rothwell, Peter M.
中科院分区：
文献类型：
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作者：
Chandratheva, Arvind;Geraghty, Olivia C.;Rothwell, Peter M.
背景和目的-ABCD(2) 评分可预测短暂性脑缺血发作 (TIA) 后发生中风的早期风险。然而，有关重复事件严重程度的数据也很有用。高分患者是否也有更严重的早期复发性中风，也许进一步证明住院是合理的？分数低的患者复发 TIA 和复发中风的早期风险是否较低？方法 - 我们在英国牛津郡完成了一项前瞻性、基于人群的研究，研究对象为 2002 年 4 月 1 日起连续 500 名出现 TIA 的患者，使用多种病例确定方法（牛津血管研究）。通过面对面随访确定复发性 TIA、轻微中风和严重中风（首次评估时美国国立卫生研究院中风量表评分 >3）。预测值表示为受试者工作特征曲线下面积。 结果 - 在 500 名 TIA 患者中，55 名患者在 7 天内复发 TIA（11.0%；95% CI，8.3% 至 13.7%），50 名患者在 7 天内复发卒中（10.0%；95% CI，7.5% 至 12.0%）。 ABCD(2) 评分高度预测主要复发性卒中（受试者工作特征曲线下面积 = 0.80；95% CI，0.72 至 0.87，P
Background and Purpose-The ABCD(2) score predicts the early risk of stroke after transient ischemic attack (TIA). However, data on the severity of recurrent events would also be useful. Do patients with high scores also have more severe early recurrent strokes, perhaps further justifying hospital admission? Do patients with low scores have a low early risk of recurrent TIA as well as recurrent stroke?Methods-We completed a prospective, population-based study in Oxfordshire, England, of 500 consecutive patients presenting with TIA from April 1, 2002, by using multiple methods of case ascertainment (Oxford Vascular Study). Recurrent TIA, minor stroke, and major stroke (National Institutes of Health Stroke Scale score >3 at the time of first assessment) were identified by face-to-face follow-up. Predictive value was expressed as the area under the receiver operating characteristic curve.Results-Of 500 patients with TIA, 55 had a recurrent TIA (11.0%; 95% CI, 8.3% to 13.7%) and 50 had a recurrent stroke (10.0%; 95% CI, 7.5% to 12.0%) within 7 days. The ABCD(2) score was highly predictive of major recurrent stroke (area under the receiver operating characteristic curve=0.80; 95% CI, 0.72 to 0.87, P