Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019
Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019
复制标题
DOI：
10.3201/eid2511.190757
复制
发表时间：
2019-11-01
影响因子：
11.8
通讯作者：
Odagiri, Takato
中科院分区：
文献类型：
--
作者：
Takashita, Emi;Ichikawa, Masataka;Odagiri, Takato
2019年，日本在一名未接触巴洛昔韦的婴儿和一名接受巴洛昔韦治疗的兄弟姐妹中检测到甲型流感（H3N2）病毒在聚合酶酸性基因中携带I38T取代，从而降低了对巴洛昔韦的易感性。这些病毒的全基因组序列是相同的，表明人与人之间的传播。应监测分离的流感病毒对巴洛韦的敏感性。
In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility.