The MoCA Well-suited screen for cognitive impairment in Parkinson disease
The MoCA Well-suited screen for cognitive impairment in Parkinson disease
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DOI：
10.1212/wnl.0b013e3181fc29c9
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发表时间：
2010-11-09
期刊：
影响因子：
9.9
通讯作者：
Anderson, T. J.
中科院分区：
文献类型：
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作者：
Dalrymple-Alford, J. C.;MacAskill, M. R.;Anderson, T. J.
目的：通过与帕金森病（PD）集中测试进行比较，确定蒙特利尔认知评估（莫卡）在筛选外部验证的帕金森病（PD）认知时的诊断准确性（帕金森病认知结局量表[SCOPA-COG]）和标准化简易精神状态检查（S-MMSE）作为基准。在运动障碍中心对114例特发性PD患者和47例健康对照者进行了方便样本检查。21例痴呆（PD-D）患者采用运动障碍协会标准进行诊断，并通过详细的独立功能和神经心理学测试进行外部验证。21例轻度认知功能障碍（PD-MCI）患者在4个认知领域中的1个中至少有2项测量结果低于正常数据1.5 SD或以上。结果：使用受试者工作特征（ROC）曲线分析的主要结果显示，所有3种精神状态测试均能很好地区分PD-D与非痴呆患者（曲线下面积[AUC]，87%-91%）和PD-MCI与PD-N患者（AUC，78%-90%），但莫卡通常更适合两种评估。最佳莫卡筛选截止值为
Objective: To establish the diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) when screening externally validated cognition in Parkinson disease (PD), by comparison with a PD-focused test (Scales for Outcomes in Parkinson disease-Cognition [SCOPA-COG]) and the standardized Mini-Mental State Examination (S-MMSE) as benchmarks.Methods: A convenience sample of 114 patients with idiopathic PD and 47 healthy controls was examined in a movement disorders center. The 21 patients with dementia (PD-D) were diagnosed using Movement Disorders Society criteria, externally validated by detailed independent functional and neuropsychological tests. The 21 patients with mild cognitive impairment (PD-MCI) scored 1.5 SD or more below normative data in at least 2 measures in 1 of 4 cognitive domains. Other patients had normal cognition (PD-N).Results: Primary outcomes using receiver operating characteristic (ROC) curve analyses showed that all 3 mental status tests produced excellent discrimination of PD-D from patients without dementia (area under the curve [AUC], 87%-91%) and PD-MCI from PD-N patients (AUC, 78%-90%), but the MoCA was generally better suited across both assessments. The optimal MoCA screening cutoffs were