Effect of granulocytopenia on extravascular lung water content after microembolization.
Effect of granulocytopenia on extravascular lung water content after microembolization.
复制标题
粒细胞减少症对微栓塞术后血管外肺水含量的影响。
DOI：
10.1164/arrd.1980.122.4.561
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Malik,AB
中科院分区：
文献类型：
--
作者：
Johnson,A;Malik,AB
我们研究了肺微栓塞后粒细胞在肺中的滞留，以了解它是否有助于血管外含水量的增加。通过静脉注射非硅化玻璃珠（直径100 μ m）对正常犬和每日注射羟基脲造成粒细胞减少的犬进行肺栓塞。羟基脲未显著改变血小板和纤维蛋白原浓度。对照组和给药组犬的栓塞程度相同，导致肺动脉压和肺血管阻力增加相似。栓塞后对照组和治疗组的血管外肺含水量/无血肺干重（W/D）比值分别与对照组和治疗非栓塞组的W/D比值进行比较。栓塞后75 min，W/D比值从对照组的2.84 ± 0.22ml/g增加到4.54 ± 0.19ml/g（增加60%）（p < 0.05）。然而，对照-粒细胞减少组的W/D比为3.54 ± 0.19 ml/g，与栓塞后粒细胞减少组的值4.09 ± 0.27 ml/g无显著差异。由于粒细胞减少后栓塞仅使血管外肺含水量增加16%，而相同程度栓塞后治疗组增加60%，因此结果表明微栓塞后粒细胞滞留在肺中有助于肺水肿的发展。
We studied granulocyte entrapment in the lung after pulmonary microembolization to see if it contributes to the increase in extravascular water content. The lungs were embolized by intravenous injection of non-siliconized glass beads (100 εm in diameter) in normal dogs and dogs made granulocytopenic by daily injections of hydroxyurea. Hydroxyurea did not significantly alter the platelet and fibrinogen concentrations. Control and treated dogs were embolized to the same degree, which resulted in similar increases in pulmonary arterial pressure and pulmonary vascular resistance. The extravascular lung water content/bloodless dry lung weight (W/D) ratios in the control and treated groups after embolization were compared with the W/D ratios in the control and treated nonembolized groups, respectively. The W/D ratio increased from the value of 2.84 ± 0.22 ml/g in the control group to 4.54 ± 0.19 ml/g at 75 min after embolization (60% increase) (p < 0.05). However, the W/D ratio in the control-granulocytopenic group of 3.54 ± 0.19 ml/g was not significantly different from the value of 4.09 ± 0.27 ml/g in the granulocytopenic group after embolization. Because embolization after granulocytopenia produced only a 16% increase in the extravascular lung water content, compared with a 60% increase in the treated group after the same degree of embolization, the results suggested that granulocyte entrapment in the lung after microembolization contributes to the development of pulmonary edema.