FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation.
FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation.
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DOI：
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发表时间：
2000-11
期刊：
影响因子：
4.6
通讯作者：
S. Soyal;A. Amleh;J. Dean
中科院分区：
文献类型：
--
作者：
S. Soyal;A. Amleh;J. Dean
原始卵泡在哺乳动物卵巢围产期形成，出生时代表生殖细胞的终身补充。随着周期性的周期性，队列进入一个生长阶段，最终在成熟卵子排卵，但很少有人知道有关的监管级联这些事件。FIGalpha是一种参与出生后卵母细胞特异性基因表达的转录因子，早在胚胎第13天就被检测到。通过在胚胎干细胞中的靶向诱变建立缺乏FIGalpha的小鼠系。虽然胚胎性腺发生似乎正常，但原始卵泡在出生时没有形成，卵母细胞的大量消耗导致卵巢萎缩和女性不育。图（）（FIGalpha基因缺失的雄性具有正常的生育能力。无效雌性不表达Zp1、Zp2或Zp3的额外观察结果表明，FIGalpha在多个卵母细胞特异性基因的表达中起关键调节作用，所述多个卵母细胞特异性基因包括启动卵泡发生的基因和编码受精和早期胚胎存活所需的透明质酸的基因。FIGalpha在成年女性中的持续存在表明它可能调节对正常卵巢发育至关重要的其他途径。
Primordial follicles are formed perinatally in mammalian ovaries and at birth represent the lifetime complement of germ cells. With cyclic periodicity, cohorts enter into a growth phase that culminates in ovulation of mature eggs, but little is known about the regulatory cascades that govern these events. FIGalpha, a transcription factor implicated in postnatal oocyte-specific gene expression, is detected as early as embryonic day 13. Mouse lines lacking FIGalpha were established by targeted mutagenesis in embryonic stem cells. Although embryonic gonadogenesis appeared normal, primordial follicles were not formed at birth, and massive depletion of oocytes resulted in shrunken ovaries and female sterility. Fig() (the gene for FIGalpha null males have normal fertility. The additional observation that null females do not express Zp1, Zp2 or Zp3 indicates that FIGalpha plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida required for fertilization and early embryonic survival. The persistence of FIGalpha in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development.