Association of helminth infection with decreased reticulocyte counts and hemoglobin concentration in Thai falciparum malaria
Association of helminth infection with decreased reticulocyte counts and hemoglobin concentration in Thai falciparum malaria
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DOI：
10.4269/ajtmh.2001.65.335
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发表时间：
2001-10-01
影响因子：
3.3
通讯作者：
Looareesuwan, S
中科院分区：
文献类型：
--
作者：
Nacher, M;Singhasivanon, P;Looareesuwan, S
Following a study showing an association between Ascaris and protection from cerebral malaria, we conducted a cross-sectional study comparing admission hemoglobin concentrations in relation to exposure to helminth infection in 2 separate groups of patients: 111 cerebral malaria cases and 180 mild Plasmodium falciparum malaria cases. Hookworm infections were excluded. Mean hemoglobin concentrations were significantly lower in helminth-infected patients compared to those without helminths, both in the cerebral malaria group (10.1 +/- 3 [n = 47] versus 11.2 +/- 2.4 g/dl [n = 64], P = 0.04) and the mild malaria group (11 +/- 2.5 [n = 89] vs 12.2 +/- 2.7 g/dl [n = 91], P = 0.004). Median reticulocyte counts, only available in the cerebral malaria group, were lower in helminth-infected patients compared to those without helminths (15,340/23,760 per mul, P = 0.03). Adjustments for confounders such as body mass index did not alter these associations. These data are consistent with a mechanism causing anemia linked to differences in the immune response of helminth-infected patients during malaria.
